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Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes

Acyldepsipeptide (ADEP) is an exploratory antibiotic with a novel mechanism of action. ClpP, the proteolytic core of the caseinolytic protease, is deregulated towards unrestrained proteolysis. Here, we report on the mechanism of ADEP resistance in Firmicutes. This bacterial phylum contains important...

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Detalles Bibliográficos
Autores principales:	Malik, Imran T., Pereira, Rebeca, Vielberg, Marie‐Theres, Mayer, Christian, Straetener, Jan, Thomy, Dhana, Famulla, Kirsten, Castro, Helena, Sass, Peter, Groll, Michael, Brötz‐Oesterhelt, Heike
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496096/ https://www.ncbi.nlm.nih.gov/pubmed/32181548 http://dx.doi.org/10.1002/cbic.201900787

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