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The Selectivity of Fosfosal for STAT5b over STAT5a is Mediated by Arg566 in the Linker Domain
Fosfosal is the O‐phosphorylated derivative of salicylic acid, with documented clinical use as a prodrug for the treatment of inflammatory diseases. We recently discovered that fosfosal itself inhibits the protein‐protein interaction domain, the SH2 domain, of the tumor‐related transcription factor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496286/ https://www.ncbi.nlm.nih.gov/pubmed/32227557 http://dx.doi.org/10.1002/cbic.202000111 |