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Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children
BACKGROUND AND AIM: The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise‐induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remain limited. Our aim was to investiga...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496314/ https://www.ncbi.nlm.nih.gov/pubmed/32491255 http://dx.doi.org/10.1111/cpf.12647 |
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author | Burman, Janne Elenius, Varpu Lukkarinen, Heikki Kuusela, Tom Mäkelä, Mika J. Kesti, Olli Väätäinen, Katri Maunula, Maria Remes, Sami Jartti, Tuomas |
author_facet | Burman, Janne Elenius, Varpu Lukkarinen, Heikki Kuusela, Tom Mäkelä, Mika J. Kesti, Olli Väätäinen, Katri Maunula, Maria Remes, Sami Jartti, Tuomas |
author_sort | Burman, Janne |
collection | PubMed |
description | BACKGROUND AND AIM: The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise‐induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remain limited. Our aim was to investigate EVH testing feasibility among children, diagnostic testing cut‐off values, and which factors affect testing outcomes. METHODS: We recruited 134 patients aged 10–16 years with a history of exercise‐induced dyspnoea and 100 healthy control children to undergo 6‐min EVH testing. Testing feasibility was assessed by the children's ability to achieve ≥70% of the target minute ventilation of 30 times forced expiratory volume in 1 s (FEV1). Bronchoconstriction was assessed as a minimum of 8%, 10%, 12%, 15% or 20% fall in FEV1. Patient characteristics were correlated with EVH outcomes. RESULTS: Overall, 98% of the children reached ≥70%, 88% reached ≥80%, 79% reached ≥90% and 62% reached ≥100% of target ventilation in EVH testing; of children with a history of exercise‐induced dyspnoea, the decline percentages were as follows: 24% (≥8% fall), 17% (≥10% fall), 10% (≥12% fall), 6% (≥15% fall) and 5% (≥20% fall) in FEV1, compared to 11%, 4%, 3%, 1% and 0% among the healthy controls, respectively. Healthy controls and boys performed testing at higher ventilation rates (p < .05). CONCLUSION: Eucapnic voluntary hyperventilation testing is feasible among children aged 10–16 years and has diagnostic value in evaluating exercise‐induced dyspnoea among children. A minimum 10% fall in FEV1 is a good diagnostic cut‐off value. Disease status appears to be important covariates. |
format | Online Article Text |
id | pubmed-7496314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74963142020-09-25 Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children Burman, Janne Elenius, Varpu Lukkarinen, Heikki Kuusela, Tom Mäkelä, Mika J. Kesti, Olli Väätäinen, Katri Maunula, Maria Remes, Sami Jartti, Tuomas Clin Physiol Funct Imaging Original Articles BACKGROUND AND AIM: The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise‐induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remain limited. Our aim was to investigate EVH testing feasibility among children, diagnostic testing cut‐off values, and which factors affect testing outcomes. METHODS: We recruited 134 patients aged 10–16 years with a history of exercise‐induced dyspnoea and 100 healthy control children to undergo 6‐min EVH testing. Testing feasibility was assessed by the children's ability to achieve ≥70% of the target minute ventilation of 30 times forced expiratory volume in 1 s (FEV1). Bronchoconstriction was assessed as a minimum of 8%, 10%, 12%, 15% or 20% fall in FEV1. Patient characteristics were correlated with EVH outcomes. RESULTS: Overall, 98% of the children reached ≥70%, 88% reached ≥80%, 79% reached ≥90% and 62% reached ≥100% of target ventilation in EVH testing; of children with a history of exercise‐induced dyspnoea, the decline percentages were as follows: 24% (≥8% fall), 17% (≥10% fall), 10% (≥12% fall), 6% (≥15% fall) and 5% (≥20% fall) in FEV1, compared to 11%, 4%, 3%, 1% and 0% among the healthy controls, respectively. Healthy controls and boys performed testing at higher ventilation rates (p < .05). CONCLUSION: Eucapnic voluntary hyperventilation testing is feasible among children aged 10–16 years and has diagnostic value in evaluating exercise‐induced dyspnoea among children. A minimum 10% fall in FEV1 is a good diagnostic cut‐off value. Disease status appears to be important covariates. John Wiley and Sons Inc. 2020-06-26 2020-09 /pmc/articles/PMC7496314/ /pubmed/32491255 http://dx.doi.org/10.1111/cpf.12647 Text en © 2020 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Burman, Janne Elenius, Varpu Lukkarinen, Heikki Kuusela, Tom Mäkelä, Mika J. Kesti, Olli Väätäinen, Katri Maunula, Maria Remes, Sami Jartti, Tuomas Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title | Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title_full | Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title_fullStr | Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title_full_unstemmed | Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title_short | Cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
title_sort | cut‐off values to evaluate exercise‐induced asthma in eucapnic voluntary hyperventilation test for children |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496314/ https://www.ncbi.nlm.nih.gov/pubmed/32491255 http://dx.doi.org/10.1111/cpf.12647 |
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