Modeling and Simulation of the Pharmacokinetics and Target Engagement of an Antagonist Monoclonal Antibody to Interferon‐γ–Induced Protein 10, BMS‐986184, in Healthy Participants to Guide Therapeutic Dosing

BMS‐986184 is a human, second‐generation, anti–interferon‐γ–induced protein 10 (IP‐10) monoclonal antibody. In this study the pharmacokinetics and target engagement (TE) of BMS‐986184 in healthy participants were characterized using population‐based target‐mediated drug disposition (TMDD) modeling a...

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Detalles Bibliográficos
Autores principales: Cai, Weiguo, Leil, Tarek A., Gibiansky, Leonid, Krishna, Murli, Zhang, Hongwei, Gu, Huidong, Sun, Huadong, Throup, John, Banerjee, Subhashis, Girgis, Ihab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496395/
https://www.ncbi.nlm.nih.gov/pubmed/32068354
http://dx.doi.org/10.1002/cpdd.784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496395/
https://www.ncbi.nlm.nih.gov/pubmed/32068354
http://dx.doi.org/10.1002/cpdd.784

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