Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO(2), this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling o...

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Autores principales: Destro, Gianluca, Horkka, Kaisa, Loreau, Olivier, Buisson, David‐Alexandre, Kingston, Lee, Del Vecchio, Antonio, Schou, Magnus, Elmore, Charles S., Taran, Frédéric, Cantat, Thibault, Audisio, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496475/
https://www.ncbi.nlm.nih.gov/pubmed/32348625
http://dx.doi.org/10.1002/anie.202002341
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author Destro, Gianluca
Horkka, Kaisa
Loreau, Olivier
Buisson, David‐Alexandre
Kingston, Lee
Del Vecchio, Antonio
Schou, Magnus
Elmore, Charles S.
Taran, Frédéric
Cantat, Thibault
Audisio, Davide
author_facet Destro, Gianluca
Horkka, Kaisa
Loreau, Olivier
Buisson, David‐Alexandre
Kingston, Lee
Del Vecchio, Antonio
Schou, Magnus
Elmore, Charles S.
Taran, Frédéric
Cantat, Thibault
Audisio, Davide
author_sort Destro, Gianluca
collection PubMed
description A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO(2), this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [(14)C] and [(13)C]. A proof of concept with [(11)C] was also obtained with low molar activity valuable for distribution studies.
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spelling pubmed-74964752020-09-25 Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids Destro, Gianluca Horkka, Kaisa Loreau, Olivier Buisson, David‐Alexandre Kingston, Lee Del Vecchio, Antonio Schou, Magnus Elmore, Charles S. Taran, Frédéric Cantat, Thibault Audisio, Davide Angew Chem Int Ed Engl Communications A transition‐metal‐free carbon isotope exchange procedure on phenyl acetic acids is described. Utilizing the universal precursor CO(2), this protocol allows the carbon isotope to be inserted into the carboxylic acid position, with no need of precursor synthesis. This procedure enabled the labeling of 15 pharmaceuticals and was compatible with carbon isotopes [(14)C] and [(13)C]. A proof of concept with [(11)C] was also obtained with low molar activity valuable for distribution studies. John Wiley and Sons Inc. 2020-05-27 2020-08-03 /pmc/articles/PMC7496475/ /pubmed/32348625 http://dx.doi.org/10.1002/anie.202002341 Text en © 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Communications
Destro, Gianluca
Horkka, Kaisa
Loreau, Olivier
Buisson, David‐Alexandre
Kingston, Lee
Del Vecchio, Antonio
Schou, Magnus
Elmore, Charles S.
Taran, Frédéric
Cantat, Thibault
Audisio, Davide
Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title_full Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title_fullStr Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title_full_unstemmed Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title_short Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids
title_sort transition‐metal‐free carbon isotope exchange of phenyl acetic acids
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496475/
https://www.ncbi.nlm.nih.gov/pubmed/32348625
http://dx.doi.org/10.1002/anie.202002341
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