Expanding the Diversity of Plant Monoterpenoid Indole Alkaloids Employing Human Cytochrome P450 3A4

Human drug‐metabolizing cytochrome P450 monooxygenases (CYPs) have enormous substrate promiscuity; this makes them promising tools for the expansion of natural product diversity. Here, we used CYP3A4 for the targeted diversification of a plant biosynthetic route leading to monoterpenoid indole alkal...

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Detalles Bibliográficos
Autores principales: Sheludko, Yuriy V., Volk, Jascha, Brandt, Wolfgang, Warzecha, Heribert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496586/
https://www.ncbi.nlm.nih.gov/pubmed/32181956
http://dx.doi.org/10.1002/cbic.202000020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496586/
https://www.ncbi.nlm.nih.gov/pubmed/32181956
http://dx.doi.org/10.1002/cbic.202000020

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