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Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans

BACKGROUND AND AIMS: Genetically modified mice have been used extensively to study human disease. However, the data gained are not always translatable to humans because of major species differences. Liver‐humanized mice (LHM) are considered a promising model to study human hepatic and systemic metab...

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Detalles Bibliográficos
Autores principales:	Minniti, Mirko E., Pedrelli, Matteo, Vedin, Lise‐Lotte, Delbès, Anne‐Sophie, Denis, Raphaël G.P., Öörni, Katariina, Sala, Claudia, Pirazzini, Chiara, Thiagarajan, Divya, Nurmi, Harri J., Grompe, Markus, Mills, Kevin, Garagnani, Paolo, Ellis, Ewa C.S., Strom, Stephen C., Luquet, Serge H., Wilson, Elizabeth M., Bial, John, Steffensen, Knut R., Parini, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496592/ https://www.ncbi.nlm.nih.gov/pubmed/31785104 http://dx.doi.org/10.1002/hep.31052

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