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Heterologous Expression of Immature Forms of Human Islet Amyloid Polypeptide in Yeast Triggers Intracellular Aggregation and Cytotoxicity

Diabetes is a major public health issue that has attained alarming levels worldwide. Pancreatic aggregates of human islet amyloid polypeptide (IAPP) represent a major histopathological hallmark of type 2 diabetes. IAPP is expressed in β-cells as pre-pro-IAPP (ppIAPP) that is first processed to pro-I...

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Detalles Bibliográficos
Autores principales:	Raimundo, Ana F., Ferreira, Sofia, Farrim, Maria I., Santos, Cláudia N., Menezes, Regina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496629/ https://www.ncbi.nlm.nih.gov/pubmed/33013747 http://dx.doi.org/10.3389/fmicb.2020.02035

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