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Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging
Preterm birth (PTB) is a leading cause of neurodevelopmental and neurocognitive impairment in childhood and is closely associated with psychiatric disease. The biological and environmental factors that confer risk and resilience for healthy brain development and long‐term outcome after PTB are uncer...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496638/ https://www.ncbi.nlm.nih.gov/pubmed/31747472 http://dx.doi.org/10.1111/nan.12589 |
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author | Boardman, J. P. Counsell, S. J. |
author_facet | Boardman, J. P. Counsell, S. J. |
author_sort | Boardman, J. P. |
collection | PubMed |
description | Preterm birth (PTB) is a leading cause of neurodevelopmental and neurocognitive impairment in childhood and is closely associated with psychiatric disease. The biological and environmental factors that confer risk and resilience for healthy brain development and long‐term outcome after PTB are uncertain, which presents challenges for risk stratification and for the discovery and evaluation of neuroprotective strategies. Neonatal magnetic resonance imaging reveals a signature of PTB that includes dysconnectivity of neural networks and atypical development of cortical and deep grey matter structures. Here we provide a brief review of perinatal factors that are associated with the MRI signature of PTB. We consider maternal and foetal factors including chorioamnionitis, foetal growth restriction, socioeconomic deprivation and prenatal alcohol, drug and stress exposures; and neonatal factors including co‐morbidities of PTB, nutrition, pain and medication during neonatal intensive care and variation conferred by the genome/epigenome. Association studies offer the first insights into pathways to adversity and resilience after PTB. Future challenges are to analyse quantitative brain MRI data with collateral biological and environmental data in study designs that support causal inference, and ultimately to use the output of such analyses to stratify infants for clinical trials of therapies designed to improve outcome. |
format | Online Article Text |
id | pubmed-7496638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74966382020-09-25 Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging Boardman, J. P. Counsell, S. J. Neuropathol Appl Neurobiol Invited Review Preterm birth (PTB) is a leading cause of neurodevelopmental and neurocognitive impairment in childhood and is closely associated with psychiatric disease. The biological and environmental factors that confer risk and resilience for healthy brain development and long‐term outcome after PTB are uncertain, which presents challenges for risk stratification and for the discovery and evaluation of neuroprotective strategies. Neonatal magnetic resonance imaging reveals a signature of PTB that includes dysconnectivity of neural networks and atypical development of cortical and deep grey matter structures. Here we provide a brief review of perinatal factors that are associated with the MRI signature of PTB. We consider maternal and foetal factors including chorioamnionitis, foetal growth restriction, socioeconomic deprivation and prenatal alcohol, drug and stress exposures; and neonatal factors including co‐morbidities of PTB, nutrition, pain and medication during neonatal intensive care and variation conferred by the genome/epigenome. Association studies offer the first insights into pathways to adversity and resilience after PTB. Future challenges are to analyse quantitative brain MRI data with collateral biological and environmental data in study designs that support causal inference, and ultimately to use the output of such analyses to stratify infants for clinical trials of therapies designed to improve outcome. John Wiley and Sons Inc. 2019-12-12 2020-08 /pmc/articles/PMC7496638/ /pubmed/31747472 http://dx.doi.org/10.1111/nan.12589 Text en © 2019 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Review Boardman, J. P. Counsell, S. J. Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title | Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title_full | Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title_fullStr | Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title_full_unstemmed | Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title_short | Invited Review: Factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
title_sort | invited review: factors associated with atypical brain development in preterm infants: insights from magnetic resonance imaging |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496638/ https://www.ncbi.nlm.nih.gov/pubmed/31747472 http://dx.doi.org/10.1111/nan.12589 |
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