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Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling

Adaptive angiogenesis is necessary for tissue repair, however, it may also be associated with the exacerbation of injury and development of chronic disease. In these studies, we demonstrate that lung mesenchymal vascular progenitor cells (MVPC) modulate adaptive angiogenesis via lineage trace, deple...

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Autores principales: Summers, Megan E., Richmond, Bradley W., Menon, Swapna, Sheridan, Ryan M., Kropski, Jonathan A., Majka, Sarah A., Taketo, M. Mark, Bastarache, Julie A., West, James D., De Langhe, Stijn, Geraghty, Patrick, Klemm, Dwight J., Chu, Hong Wei, Friedman, Rachel S., Tao, Yuankai K., Foronjy, Robert F., Majka, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496763/
https://www.ncbi.nlm.nih.gov/pubmed/32533805
http://dx.doi.org/10.1096/fj.202000629R
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author Summers, Megan E.
Richmond, Bradley W.
Menon, Swapna
Sheridan, Ryan M.
Kropski, Jonathan A.
Majka, Sarah A.
Taketo, M. Mark
Bastarache, Julie A.
West, James D.
De Langhe, Stijn
Geraghty, Patrick
Klemm, Dwight J.
Chu, Hong Wei
Friedman, Rachel S.
Tao, Yuankai K.
Foronjy, Robert F.
Majka, Susan M.
author_facet Summers, Megan E.
Richmond, Bradley W.
Menon, Swapna
Sheridan, Ryan M.
Kropski, Jonathan A.
Majka, Sarah A.
Taketo, M. Mark
Bastarache, Julie A.
West, James D.
De Langhe, Stijn
Geraghty, Patrick
Klemm, Dwight J.
Chu, Hong Wei
Friedman, Rachel S.
Tao, Yuankai K.
Foronjy, Robert F.
Majka, Susan M.
author_sort Summers, Megan E.
collection PubMed
description Adaptive angiogenesis is necessary for tissue repair, however, it may also be associated with the exacerbation of injury and development of chronic disease. In these studies, we demonstrate that lung mesenchymal vascular progenitor cells (MVPC) modulate adaptive angiogenesis via lineage trace, depletion of MVPC, and modulation of β‐catenin expression. Single cell sequencing confirmed MVPC as multipotential vascular progenitors, thus, genetic depletion resulted in alveolar simplification with reduced adaptive angiogenesis. Following vascular endothelial injury, Wnt activation in MVPC was sufficient to elicit an emphysema‐like phenotype characterized by increased MLI, fibrosis, and MVPC driven adaptive angiogenesis. Lastly, activation of Wnt/β‐catenin signaling skewed the profile of human and murine MVPC toward an adaptive phenotype. These data suggest that lung MVPC drive angiogenesis in response to injury and regulate the microvascular niche as well as subsequent distal lung tissue architecture via Wnt signaling.
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spelling pubmed-74967632020-09-25 Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling Summers, Megan E. Richmond, Bradley W. Menon, Swapna Sheridan, Ryan M. Kropski, Jonathan A. Majka, Sarah A. Taketo, M. Mark Bastarache, Julie A. West, James D. De Langhe, Stijn Geraghty, Patrick Klemm, Dwight J. Chu, Hong Wei Friedman, Rachel S. Tao, Yuankai K. Foronjy, Robert F. Majka, Susan M. FASEB J Research Articles Adaptive angiogenesis is necessary for tissue repair, however, it may also be associated with the exacerbation of injury and development of chronic disease. In these studies, we demonstrate that lung mesenchymal vascular progenitor cells (MVPC) modulate adaptive angiogenesis via lineage trace, depletion of MVPC, and modulation of β‐catenin expression. Single cell sequencing confirmed MVPC as multipotential vascular progenitors, thus, genetic depletion resulted in alveolar simplification with reduced adaptive angiogenesis. Following vascular endothelial injury, Wnt activation in MVPC was sufficient to elicit an emphysema‐like phenotype characterized by increased MLI, fibrosis, and MVPC driven adaptive angiogenesis. Lastly, activation of Wnt/β‐catenin signaling skewed the profile of human and murine MVPC toward an adaptive phenotype. These data suggest that lung MVPC drive angiogenesis in response to injury and regulate the microvascular niche as well as subsequent distal lung tissue architecture via Wnt signaling. John Wiley and Sons Inc. 2020-06-13 2020-08 /pmc/articles/PMC7496763/ /pubmed/32533805 http://dx.doi.org/10.1096/fj.202000629R Text en © 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Summers, Megan E.
Richmond, Bradley W.
Menon, Swapna
Sheridan, Ryan M.
Kropski, Jonathan A.
Majka, Sarah A.
Taketo, M. Mark
Bastarache, Julie A.
West, James D.
De Langhe, Stijn
Geraghty, Patrick
Klemm, Dwight J.
Chu, Hong Wei
Friedman, Rachel S.
Tao, Yuankai K.
Foronjy, Robert F.
Majka, Susan M.
Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title_full Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title_fullStr Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title_full_unstemmed Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title_short Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling
title_sort resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical wnt signaling
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496763/
https://www.ncbi.nlm.nih.gov/pubmed/32533805
http://dx.doi.org/10.1096/fj.202000629R
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