Cargando…

Glial Cell Line–Derived Neurotrophic Factor Receptor Rearranged During Transfection Agonist Supports Dopamine Neurons In Vitro and Enhances Dopamine Release In Vivo

BACKGROUND: Motor symptoms of Parkinson's disease (PD) are caused by degeneration and progressive loss of nigrostriatal dopamine neurons. Currently, no cure for this disease is available. Existing drugs alleviate PD symptoms but fail to halt neurodegeneration. Glial cell line–derived neurotroph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mahato, Arun Kumar, Kopra, Jaakko, Renko, Juho‐Matti, Visnapuu, Tanel, Korhonen, Ilari, Pulkkinen, Nita, Bespalov, Maxim M., Domanskyi, Andrii, Ronken, Eric, Piepponen, T. Petteri, Voutilainen, Merja H., Tuominen, Raimo K., Karelson, Mati, Sidorova, Yulia A., Saarma, Mart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496767/ https://www.ncbi.nlm.nih.gov/pubmed/31840869 http://dx.doi.org/10.1002/mds.27943

Ejemplares similares

Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats
por: Renko, Juho-Matti, et al.
Publicado: (2021)

Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Elevates Stimulus-Evoked Release of Dopamine in Freely-Moving Rats
por: Renko, Juho-Matti, et al.
Publicado: (2018)

GDNF Receptor Agonist Alleviates Motor Imbalance in Unilateral 6-Hydroxydopamine Model of Parkinson’s Disease
por: Renko, Juho-Matti, et al.
Publicado: (2020)

MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System
por: Pakarinen, Emmi, et al.
Publicado: (2020)

Cerebral dopamine neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice
por: Lindahl, Maria, et al.
Publicado: (2019)

Small-Molecule Ligands as Potential GDNF Family Receptor Agonists
por: Ivanova, Larisa, et al.
Publicado: (2018)

Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons
por: Selberg, Simona, et al.
Publicado: (2021)

Implementation of deep neural networks to count dopamine neurons in substantia nigra
por: Penttinen, Anna‐Maija, et al.
Publicado: (2018)

Cerebral dopamine neurotrophic factor protects and repairs dopamine neurons by novel mechanism
por: Lindholm, Päivi, et al.
Publicado: (2021)

Dicer and microRNAs protect adult dopamine neurons
por: Chmielarz, Piotr, et al.
Publicado: (2017)

Permeation of Dopamine Sulfate through the Blood-Brain Barrier
por: Suominen, Tina, et al.
Publicado: (2015)

Molecular Dynamics Simulations of the Interactions between Glial Cell Line-Derived Neurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands
por: Ivanova, Larisa, et al.
Publicado: (2018)

Cerebral Dopamine Neurotrophic Factor Diffuses Around the Brainstem and Does Not Undergo Anterograde Transport After Injection to the Substantia Nigra
por: Albert, Katrina, et al.
Publicado: (2019)

A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat
por: Sidorova, Yulia A., et al.
Publicado: (2017)

Increased Physiological GDNF Levels Have No Effect on Dopamine Neuron Protection and Restoration in a Proteasome Inhibition Mouse Model of Parkinson’s Disease
por: Olfat, Soophie, et al.
Publicado: (2023)

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease Models
por: Albert, Katrina, et al.
Publicado: (2017)

Cerebral dopamine neurotrophic factor reduces α-synuclein aggregation and propagation and alleviates behavioral alterations in vivo
por: Albert, Katrina, et al.
Publicado: (2021)

Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP(+) in dissociated cultures from rat mesencephalon
por: Jaumotte, Juliann D., et al.
Publicado: (2021)

Netrin‐1 and its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features
por: Jasmin, Mélissa, et al.
Publicado: (2020)

Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT
por: Pitkonen, Miia, et al.
Publicado: (2012)

Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration
por: Fernandez-Parrilla, Manuel A., et al.
Publicado: (2021)

Small Molecules and Peptides Targeting Glial Cell Line-Derived Neurotrophic Factor Receptors for the Treatment of Neurodegeneration
por: Sidorova, Yulia A., et al.
Publicado: (2020)

Dopamine System, NMDA Receptor and EGF Family Expressions in Brain Structures of Bl6 and 129Sv Strains Displaying Different Behavioral Adaptation
por: Varul, Jane, et al.
Publicado: (2021)

Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
por: Mätlik, Kärt, et al.
Publicado: (2022)

Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model
por: Lindström, Riitta, et al.
Publicado: (2013)

Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance
por: Domanskyi, Andrii, et al.
Publicado: (2014)

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease
por: Penttinen, Anna-Maija, et al.
Publicado: (2018)

Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors
por: Myslivecek, Jaromir
Publicado: (2022)

RNA Interference-Guided Targeting of Hepatitis C Virus Replication with Antisense Locked Nucleic Acid-Based Oligonucleotides Containing 8-oxo-dG Modifications
por: Mutso, Margit, et al.
Publicado: (2015)

PTPRA Phosphatase Regulates GDNF-Dependent RET Signaling and Inhibits the RET Mutant MEN2A Oncogenic Potential
por: Yadav, Leena, et al.
Publicado: (2020)

The Mechanism and Pathways of Dopamine and Dopamine Agonists in Prolactinomas
por: Liu, Xiaoshuang, et al.
Publicado: (2019)

Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin
por: Bespalov, Maxim M., et al.
Publicado: (2011)

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra
por: Nadella, Rasajna, et al.
Publicado: (2014)

Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice
por: Turconi, Giorgio, et al.
Publicado: (2020)

The Transfection of BDNF to Dopamine Neurons Potentiates the Effect of Dopamine D3 Receptor Agonist Recovering the Striatal Innervation, Dendritic Spines and Motor Behavior in an Aged Rat Model of Parkinson’s Disease
por: Razgado-Hernandez, Luis F., et al.
Publicado: (2015)

MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex
por: Tseng, Kuan-Yin, et al.
Publicado: (2017)

Correction: GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2016)

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function
por: Kumar, Anmol, et al.
Publicado: (2015)

The dopamine transporter antiports potassium to increase the uptake of dopamine
por: Schmidt, Solveig G., et al.
Publicado: (2022)

From Enzymatic Dopamine Biosensors to OECT Biosensors of Dopamine
por: Ravariu, Cristian
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_se6ug1jbhdmbqusij77k5uqb96