Food‐effect study of nilotinib in chronic myeloid leukaemia (NiFo study): Enabling dose reduction and relief of treatment burden

OBJECTIVES: Taking advantage of its food‐dependent bioavailability, the present study investigated the effect of a reduced dose taken with real‐life meals on the pharmacokinetics (PK) of nilotinib in chronic myeloid leukaemia (CML) patients. METHODS: Nilotinib was taken fasted (300 mg BID, days 1‐4)...

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Detalles Bibliográficos
Autores principales: Boons, Christel C. L. M., den Hartog, Yvonne M., Janssen, Jeroen J. W. M., Zandvliet, Anthe S., Vos, René M., Swart, Eleonora L., Hendrikse, N. Harry, Hugtenburg, Jacqueline G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496780/
https://www.ncbi.nlm.nih.gov/pubmed/32243653
http://dx.doi.org/10.1111/ejh.13418

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