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Electroretinogram abnormalities in non‐infectious uveitis often persist
PURPOSE: In uveitis, a prolonged implicit time of the cone b‐wave is a characteristic electroretinogram (ERG) abnormality. We investigated whether this can improve or deteriorate over time and which clinical factors are associated with change. METHODS: Prospective cohort study. Patients with a non‐i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496825/ https://www.ncbi.nlm.nih.gov/pubmed/32190989 http://dx.doi.org/10.1111/aos.14401 |
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author | Brouwer, Anna H. de Wit, Gerard C. ten Dam, Ninette H. Wijnhoven, Ralph van Genderen, Maria M. de Boer, Joke H. |
author_facet | Brouwer, Anna H. de Wit, Gerard C. ten Dam, Ninette H. Wijnhoven, Ralph van Genderen, Maria M. de Boer, Joke H. |
author_sort | Brouwer, Anna H. |
collection | PubMed |
description | PURPOSE: In uveitis, a prolonged implicit time of the cone b‐wave is a characteristic electroretinogram (ERG) abnormality. We investigated whether this can improve or deteriorate over time and which clinical factors are associated with change. METHODS: Prospective cohort study. Patients with a non‐infectious uveitis were included. An ERG was measured in the first year of uveitis onset and a follow‐up ERG one year later. Changes in the implicit time of the cone b‐wave were investigated in relation to clinical parameters including the following: demographics, uveitis characteristics, treatment, best‐corrected visual acuity, optical coherence tomography parameters and fluorescein angiography scores. RESULTS: Of 98 eyes (63 patients), 40 showed a prolonged cone b‐wave on the first ERG, which improved in 10 eyes. Eyes with an improved ERG more often had a panuveitis with initially a higher incidence of cells in the anterior chamber during the first ERG, which resolved at the time of their follow‐up ERG. Five of the 58 eyes with a normal first ERG had a deteriorated follow‐up ERG. These eyes had more frequently an active uveitis at the time of the follow‐up ERG. Of the 78 eyes with a stable cone b‐wave, 16 had a quiescent inflammation during follow‐up. There were no differences in age or treatment. CONCLUSION: In most patients with non‐infectious uveitis, ERG abnormalities appear to be irreversible, even when the inflammation becomes quiescent. However, some ERGs improved, which was associated with reduction in inflammation of the anterior chamber due to panuveitis. In contrast, a worsened ERG was associated with a persistence of inflammation. |
format | Online Article Text |
id | pubmed-7496825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74968252020-09-25 Electroretinogram abnormalities in non‐infectious uveitis often persist Brouwer, Anna H. de Wit, Gerard C. ten Dam, Ninette H. Wijnhoven, Ralph van Genderen, Maria M. de Boer, Joke H. Acta Ophthalmol Original Articles PURPOSE: In uveitis, a prolonged implicit time of the cone b‐wave is a characteristic electroretinogram (ERG) abnormality. We investigated whether this can improve or deteriorate over time and which clinical factors are associated with change. METHODS: Prospective cohort study. Patients with a non‐infectious uveitis were included. An ERG was measured in the first year of uveitis onset and a follow‐up ERG one year later. Changes in the implicit time of the cone b‐wave were investigated in relation to clinical parameters including the following: demographics, uveitis characteristics, treatment, best‐corrected visual acuity, optical coherence tomography parameters and fluorescein angiography scores. RESULTS: Of 98 eyes (63 patients), 40 showed a prolonged cone b‐wave on the first ERG, which improved in 10 eyes. Eyes with an improved ERG more often had a panuveitis with initially a higher incidence of cells in the anterior chamber during the first ERG, which resolved at the time of their follow‐up ERG. Five of the 58 eyes with a normal first ERG had a deteriorated follow‐up ERG. These eyes had more frequently an active uveitis at the time of the follow‐up ERG. Of the 78 eyes with a stable cone b‐wave, 16 had a quiescent inflammation during follow‐up. There were no differences in age or treatment. CONCLUSION: In most patients with non‐infectious uveitis, ERG abnormalities appear to be irreversible, even when the inflammation becomes quiescent. However, some ERGs improved, which was associated with reduction in inflammation of the anterior chamber due to panuveitis. In contrast, a worsened ERG was associated with a persistence of inflammation. John Wiley and Sons Inc. 2020-03-19 2020-09 /pmc/articles/PMC7496825/ /pubmed/32190989 http://dx.doi.org/10.1111/aos.14401 Text en © 2020 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Brouwer, Anna H. de Wit, Gerard C. ten Dam, Ninette H. Wijnhoven, Ralph van Genderen, Maria M. de Boer, Joke H. Electroretinogram abnormalities in non‐infectious uveitis often persist |
title | Electroretinogram abnormalities in non‐infectious uveitis often persist |
title_full | Electroretinogram abnormalities in non‐infectious uveitis often persist |
title_fullStr | Electroretinogram abnormalities in non‐infectious uveitis often persist |
title_full_unstemmed | Electroretinogram abnormalities in non‐infectious uveitis often persist |
title_short | Electroretinogram abnormalities in non‐infectious uveitis often persist |
title_sort | electroretinogram abnormalities in non‐infectious uveitis often persist |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496825/ https://www.ncbi.nlm.nih.gov/pubmed/32190989 http://dx.doi.org/10.1111/aos.14401 |
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