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Engineering Orthogonal Methyltransferases to Create Alternative Bioalkylation Pathways

S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases (MTs) catalyse the methylation of a vast array of small metabolites and biomacromolecules. Recently, rare carboxymethylation pathways have been discovered, including carboxymethyltransferase enzymes that utilise a carboxy‐SAM (cxSAM) cofacto...

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Detalles Bibliográficos
Autores principales:	Herbert, Abigail J., Shepherd, Sarah A., Cronin, Victoria A., Bennett, Matthew R., Sung, Rehana, Micklefield, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496830/ https://www.ncbi.nlm.nih.gov/pubmed/32402113 http://dx.doi.org/10.1002/anie.202004963

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