Topology‐Matching Design of an Influenza‐Neutralizing Spiky Nanoparticle‐Based Inhibitor with a Dual Mode of Action

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In this study, we demonstrate the concept of “topology‐matching design” for virus inhibitors. With the current knowledge of influenza A virus (IAV), we designed a nanoparticle‐based inhibitor (nano‐inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effec...

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Detalles Bibliográficos
Autores principales: Nie, Chuanxiong, Parshad, Badri, Bhatia, Sumati, Cheng, Chong, Stadtmüller, Marlena, Oehrl, Alexander, Kerkhoff, Yannic, Wolff, Thorsten, Haag, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497169/
https://www.ncbi.nlm.nih.gov/pubmed/32421225
http://dx.doi.org/10.1002/anie.202004832

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