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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands

Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating the transcription of target genes. TOP2 resolves the entanglement of genomic DNA by transiently generating double‐strand breaks (DSBs), where TOP2 homodimers covalently bind...

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Detalles Bibliográficos
Autores principales:	Al Mahmud, Md. Rasel, Ishii, Kenichiro, Bernal‐Lozano, Cristina, Delgado‐Sainz, Irene, Toi, Masakazu, Akamatsu, Shusuke, Fukumoto, Manabu, Watanabe, Masatoshi, Takeda, Shunichi, Cortés‐Ledesma, Felipe, Sasanuma, Hiroyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497232/ https://www.ncbi.nlm.nih.gov/pubmed/32277721 http://dx.doi.org/10.1111/gtc.12770

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