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Therapeutic modulation of inflammasome pathways
Inflammasomes are macromolecular complexes formed in response to pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) that drive maturation of the pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18, and cleave gasdermin D (GSDMD) for induction of pyro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497261/ https://www.ncbi.nlm.nih.gov/pubmed/32770571 http://dx.doi.org/10.1111/imr.12908 |
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author | Chauhan, Dhruv Vande Walle, Lieselotte Lamkanfi, Mohamed |
author_facet | Chauhan, Dhruv Vande Walle, Lieselotte Lamkanfi, Mohamed |
author_sort | Chauhan, Dhruv |
collection | PubMed |
description | Inflammasomes are macromolecular complexes formed in response to pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) that drive maturation of the pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18, and cleave gasdermin D (GSDMD) for induction of pyroptosis. Inflammasomes are highly important in protecting the host from various microbial pathogens and sterile insults. Inflammasome pathways are strictly regulated at both transcriptional and post‐translational checkpoints. When these checkpoints are not properly imposed, undue inflammasome activation may promote inflammatory, metabolic and oncogenic processes that give rise to autoinflammatory, autoimmune, metabolic and malignant diseases. In addition to clinically approved IL‐1‐targeted biologics, upstream targeting of inflammasome pathways recently gained interest as a novel pharmacological strategy for selectively modulating inflammasome activation in pathological conditions. |
format | Online Article Text |
id | pubmed-7497261 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74972612020-09-25 Therapeutic modulation of inflammasome pathways Chauhan, Dhruv Vande Walle, Lieselotte Lamkanfi, Mohamed Immunol Rev Invited Reviews Inflammasomes are macromolecular complexes formed in response to pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) that drive maturation of the pro‐inflammatory cytokines interleukin (IL)‐1β and IL‐18, and cleave gasdermin D (GSDMD) for induction of pyroptosis. Inflammasomes are highly important in protecting the host from various microbial pathogens and sterile insults. Inflammasome pathways are strictly regulated at both transcriptional and post‐translational checkpoints. When these checkpoints are not properly imposed, undue inflammasome activation may promote inflammatory, metabolic and oncogenic processes that give rise to autoinflammatory, autoimmune, metabolic and malignant diseases. In addition to clinically approved IL‐1‐targeted biologics, upstream targeting of inflammasome pathways recently gained interest as a novel pharmacological strategy for selectively modulating inflammasome activation in pathological conditions. John Wiley and Sons Inc. 2020-08-07 2020-09 /pmc/articles/PMC7497261/ /pubmed/32770571 http://dx.doi.org/10.1111/imr.12908 Text en © 2020 The Authors. Immunological Reviews published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Reviews Chauhan, Dhruv Vande Walle, Lieselotte Lamkanfi, Mohamed Therapeutic modulation of inflammasome pathways |
title | Therapeutic modulation of inflammasome pathways |
title_full | Therapeutic modulation of inflammasome pathways |
title_fullStr | Therapeutic modulation of inflammasome pathways |
title_full_unstemmed | Therapeutic modulation of inflammasome pathways |
title_short | Therapeutic modulation of inflammasome pathways |
title_sort | therapeutic modulation of inflammasome pathways |
topic | Invited Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497261/ https://www.ncbi.nlm.nih.gov/pubmed/32770571 http://dx.doi.org/10.1111/imr.12908 |
work_keys_str_mv | AT chauhandhruv therapeuticmodulationofinflammasomepathways AT vandewallelieselotte therapeuticmodulationofinflammasomepathways AT lamkanfimohamed therapeuticmodulationofinflammasomepathways |