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The Prevalence of Celiac Disease in a Fracture Liaison Service Population
Celiac disease (CD) is a known risk factor for osteoporosis and fractures. The prevalence of CD in patients with a recent fracture is unknown. We therefore systematically screened patients at a fracture liaison service (FLS) to study the prevalence of CD. Patients with a recent fracture aged ≥ 50 ye...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497300/ https://www.ncbi.nlm.nih.gov/pubmed/32725291 http://dx.doi.org/10.1007/s00223-020-00725-z |
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author | de Bruin, Irma J. A. Vranken, Lisanne Wyers, Caroline E. van der Velde, Robert Y. Trienekens, Thera A. M. Kaarsemaker, Sjoerd Janzing, Heinrich M. J. Wolters, Frank L. Wouda, Siep Geusens, Piet P. M. M. van den Bergh, Joop P. W. |
author_facet | de Bruin, Irma J. A. Vranken, Lisanne Wyers, Caroline E. van der Velde, Robert Y. Trienekens, Thera A. M. Kaarsemaker, Sjoerd Janzing, Heinrich M. J. Wolters, Frank L. Wouda, Siep Geusens, Piet P. M. M. van den Bergh, Joop P. W. |
author_sort | de Bruin, Irma J. A. |
collection | PubMed |
description | Celiac disease (CD) is a known risk factor for osteoporosis and fractures. The prevalence of CD in patients with a recent fracture is unknown. We therefore systematically screened patients at a fracture liaison service (FLS) to study the prevalence of CD. Patients with a recent fracture aged ≥ 50 years were invited to VieCuri Medical Center’s FLS. In FLS attendees, bone mineral density (BMD) and laboratory evaluation for metabolic bone disorders and serological screening for CD was systematically evaluated. If serologic testing for CD was positive, duodenal biopsies were performed to confirm the diagnosis CD. Data were collected in 1042 consecutive FLS attendees. Median age was 66 years (Interquartile range (IQR) 15), 27.6% had a major and 6.9% a hip fracture, 26.4% had osteoporosis and 50.8% osteopenia. Prevalent vertebral fractures were found in 29.1%. CD was already diagnosed in two patients (0.19%), one still had a positive serology. Three other patients (0.29%) had a positive serology for CD (one with gastro-intestinal complaints). In two of them, CD was confirmed by duodenal histology (0.19%) and one refused further evaluation. The prevalence of biopsy-proven CD was therefore 0.38% (4/1042) of which 0.19% (2/1042) was newly diagnosed. The prevalence of CD in patients with a recent fracture at the FLS was 0.38% and within the range of reported prevalences in the Western-European population (0.33–1.5%). Newly diagnosed CD was only found in 0.19%. Therefore, standard screening for CD in FLS patients is not recommended. |
format | Online Article Text |
id | pubmed-7497300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-74973002020-09-29 The Prevalence of Celiac Disease in a Fracture Liaison Service Population de Bruin, Irma J. A. Vranken, Lisanne Wyers, Caroline E. van der Velde, Robert Y. Trienekens, Thera A. M. Kaarsemaker, Sjoerd Janzing, Heinrich M. J. Wolters, Frank L. Wouda, Siep Geusens, Piet P. M. M. van den Bergh, Joop P. W. Calcif Tissue Int Original Research Celiac disease (CD) is a known risk factor for osteoporosis and fractures. The prevalence of CD in patients with a recent fracture is unknown. We therefore systematically screened patients at a fracture liaison service (FLS) to study the prevalence of CD. Patients with a recent fracture aged ≥ 50 years were invited to VieCuri Medical Center’s FLS. In FLS attendees, bone mineral density (BMD) and laboratory evaluation for metabolic bone disorders and serological screening for CD was systematically evaluated. If serologic testing for CD was positive, duodenal biopsies were performed to confirm the diagnosis CD. Data were collected in 1042 consecutive FLS attendees. Median age was 66 years (Interquartile range (IQR) 15), 27.6% had a major and 6.9% a hip fracture, 26.4% had osteoporosis and 50.8% osteopenia. Prevalent vertebral fractures were found in 29.1%. CD was already diagnosed in two patients (0.19%), one still had a positive serology. Three other patients (0.29%) had a positive serology for CD (one with gastro-intestinal complaints). In two of them, CD was confirmed by duodenal histology (0.19%) and one refused further evaluation. The prevalence of biopsy-proven CD was therefore 0.38% (4/1042) of which 0.19% (2/1042) was newly diagnosed. The prevalence of CD in patients with a recent fracture at the FLS was 0.38% and within the range of reported prevalences in the Western-European population (0.33–1.5%). Newly diagnosed CD was only found in 0.19%. Therefore, standard screening for CD in FLS patients is not recommended. Springer US 2020-07-28 2020 /pmc/articles/PMC7497300/ /pubmed/32725291 http://dx.doi.org/10.1007/s00223-020-00725-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Research de Bruin, Irma J. A. Vranken, Lisanne Wyers, Caroline E. van der Velde, Robert Y. Trienekens, Thera A. M. Kaarsemaker, Sjoerd Janzing, Heinrich M. J. Wolters, Frank L. Wouda, Siep Geusens, Piet P. M. M. van den Bergh, Joop P. W. The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title | The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title_full | The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title_fullStr | The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title_full_unstemmed | The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title_short | The Prevalence of Celiac Disease in a Fracture Liaison Service Population |
title_sort | prevalence of celiac disease in a fracture liaison service population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497300/ https://www.ncbi.nlm.nih.gov/pubmed/32725291 http://dx.doi.org/10.1007/s00223-020-00725-z |
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