Cargando…

Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis

The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound transporters required to transport a diverse array of substrates over biological membranes. Physiologically, they are essential for nutrient uptake, ion transport and waste removal. However, accumulating evidence sugg...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutherland, Rachel, Meeson, Annette, Lowes, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497311/
https://www.ncbi.nlm.nih.gov/pubmed/32388639
http://dx.doi.org/10.1007/s10555-020-09879-6
_version_ 1783583289890570240
author Sutherland, Rachel
Meeson, Annette
Lowes, Simon
author_facet Sutherland, Rachel
Meeson, Annette
Lowes, Simon
author_sort Sutherland, Rachel
collection PubMed
description The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound transporters required to transport a diverse array of substrates over biological membranes. Physiologically, they are essential for nutrient uptake, ion transport and waste removal. However, accumulating evidence suggest that up- and/or downregulation of SLCs may play a pivotal role in the pathogenesis of human malignancy. Endogenous substrates of SLCs include oestrogen and its conjugates, the handling of which may be of importance in hormone-dependent cancers. The SLCs play a significant role in the handling of therapeutic agents including anticancer drugs. Differential SLC expression in cancers may, therefore, impact on the efficacy of treatments. However, there is also a small body of evidence to suggest the dysregulated expression of some of these transporters may be linked to cancer metastasis. This review draws on the current knowledge of the roles of SLC transporters in human cancers in order to highlight the potential significance of these solute carriers in breast cancer pathogenesis and treatment. [Figure: see text]
format Online
Article
Text
id pubmed-7497311
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-74973112020-09-29 Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis Sutherland, Rachel Meeson, Annette Lowes, Simon Cancer Metastasis Rev Non-Thematic Review The solute carrier (SLC) superfamily encompasses a large variety of membrane-bound transporters required to transport a diverse array of substrates over biological membranes. Physiologically, they are essential for nutrient uptake, ion transport and waste removal. However, accumulating evidence suggest that up- and/or downregulation of SLCs may play a pivotal role in the pathogenesis of human malignancy. Endogenous substrates of SLCs include oestrogen and its conjugates, the handling of which may be of importance in hormone-dependent cancers. The SLCs play a significant role in the handling of therapeutic agents including anticancer drugs. Differential SLC expression in cancers may, therefore, impact on the efficacy of treatments. However, there is also a small body of evidence to suggest the dysregulated expression of some of these transporters may be linked to cancer metastasis. This review draws on the current knowledge of the roles of SLC transporters in human cancers in order to highlight the potential significance of these solute carriers in breast cancer pathogenesis and treatment. [Figure: see text] Springer US 2020-05-09 2020 /pmc/articles/PMC7497311/ /pubmed/32388639 http://dx.doi.org/10.1007/s10555-020-09879-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Non-Thematic Review
Sutherland, Rachel
Meeson, Annette
Lowes, Simon
Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title_full Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title_fullStr Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title_full_unstemmed Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title_short Solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
title_sort solute transporters and malignancy: establishing the role of uptake transporters in breast cancer and breast cancer metastasis
topic Non-Thematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497311/
https://www.ncbi.nlm.nih.gov/pubmed/32388639
http://dx.doi.org/10.1007/s10555-020-09879-6
work_keys_str_mv AT sutherlandrachel solutetransportersandmalignancyestablishingtheroleofuptaketransportersinbreastcancerandbreastcancermetastasis
AT meesonannette solutetransportersandmalignancyestablishingtheroleofuptaketransportersinbreastcancerandbreastcancermetastasis
AT lowessimon solutetransportersandmalignancyestablishingtheroleofuptaketransportersinbreastcancerandbreastcancermetastasis