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Development of Potent PfCLK3 Inhibitors Based on TCMDC-135051 as a New Class of Antimalarials
[Image: see text] The protein kinase PfCLK3 plays a critical role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood stage Plasmodium falciparum. We recently validated PfCLK3 as a drug target in malaria that offers prophylactic, transmission blocking, and...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497403/ https://www.ncbi.nlm.nih.gov/pubmed/32787140 http://dx.doi.org/10.1021/acs.jmedchem.0c00451 |