Heparin-based hydrogel scaffolding alters the transcriptomic profile and increases the chemoresistance of MDA-MB-231 triple-negative breast cancer cells

The tumor microenvironment plays a critical role in the proliferation and chemoresistance of cancer cells. Growth factors (GFs) are known to interact with the extracellular matrix (ECM) via heparin binding sites, and these associations influence cell behavior. In the present study, we demonstrate th...

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Detalles Bibliográficos
Autores principales: Menon, Nidhi, Dang, Ha X., Datla, Udaya Sree, Moarefian, Maryam, Lawrence, Christopher B., Maher, Christopher A., Jones, Caroline N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497406/
https://www.ncbi.nlm.nih.gov/pubmed/32091043
http://dx.doi.org/10.1039/c9bm01481k

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