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Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults

Previous research has shown an association between cognitive control deficits and problematic behavior such as antisocial behavior and substance use, but little is known about the predictive value of cognitive control for treatment outcome. The current study tests whether selected markers of baselin...

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Autores principales: Van der Sluys, M. E., Zijlmans, J., Popma, A., Van der Laan, P. H., Scherder, E. J. A., Marhe, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497488/
https://www.ncbi.nlm.nih.gov/pubmed/32820418
http://dx.doi.org/10.3758/s13415-020-00822-4
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author Van der Sluys, M. E.
Zijlmans, J.
Popma, A.
Van der Laan, P. H.
Scherder, E. J. A.
Marhe, R.
author_facet Van der Sluys, M. E.
Zijlmans, J.
Popma, A.
Van der Laan, P. H.
Scherder, E. J. A.
Marhe, R.
author_sort Van der Sluys, M. E.
collection PubMed
description Previous research has shown an association between cognitive control deficits and problematic behavior such as antisocial behavior and substance use, but little is known about the predictive value of cognitive control for treatment outcome. The current study tests whether selected markers of baseline cognitive control predict (1) treatment completion of a day treatment program involving a combination of approaches for multiproblem young adults and (2) daytime activities a year after the start of treatment, over and above psychological, social, and criminal characteristics. We assessed individual, neurobiological, and neurobehavioral measures, including functional brain activity during an inhibition task and two electroencephalographic measures of error processing in 127 male multiproblem young adults (age 18–27 years). We performed two hierarchical regression models to test the predictive power of cognitive control for treatment completion and daytime activities at follow-up. The overall models did not significantly predict treatment completion or daytime activities at follow-up. However, activity in the anterior cingulate cortex (ACC) during response inhibition, years of regular alcohol use, internalizing problems, and ethnicity were all significant individual predictors of daytime activity at follow-up. In conclusion, cognitive control could not predict treatment completion or daytime activities a year after the start of treatment over and above individual characteristics. However, results indicate a direct association between brain activity during response inhibition and participation in daytime activities, such as work or school, after treatment. As adequate baseline inhibitory control is associated with a positive outcome at follow-up, this suggests interventions targeting cognitive control might result in better outcomes at follow-up.
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spelling pubmed-74974882020-09-29 Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults Van der Sluys, M. E. Zijlmans, J. Popma, A. Van der Laan, P. H. Scherder, E. J. A. Marhe, R. Cogn Affect Behav Neurosci Article Previous research has shown an association between cognitive control deficits and problematic behavior such as antisocial behavior and substance use, but little is known about the predictive value of cognitive control for treatment outcome. The current study tests whether selected markers of baseline cognitive control predict (1) treatment completion of a day treatment program involving a combination of approaches for multiproblem young adults and (2) daytime activities a year after the start of treatment, over and above psychological, social, and criminal characteristics. We assessed individual, neurobiological, and neurobehavioral measures, including functional brain activity during an inhibition task and two electroencephalographic measures of error processing in 127 male multiproblem young adults (age 18–27 years). We performed two hierarchical regression models to test the predictive power of cognitive control for treatment completion and daytime activities at follow-up. The overall models did not significantly predict treatment completion or daytime activities at follow-up. However, activity in the anterior cingulate cortex (ACC) during response inhibition, years of regular alcohol use, internalizing problems, and ethnicity were all significant individual predictors of daytime activity at follow-up. In conclusion, cognitive control could not predict treatment completion or daytime activities a year after the start of treatment over and above individual characteristics. However, results indicate a direct association between brain activity during response inhibition and participation in daytime activities, such as work or school, after treatment. As adequate baseline inhibitory control is associated with a positive outcome at follow-up, this suggests interventions targeting cognitive control might result in better outcomes at follow-up. Springer US 2020-08-20 2020 /pmc/articles/PMC7497488/ /pubmed/32820418 http://dx.doi.org/10.3758/s13415-020-00822-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Van der Sluys, M. E.
Zijlmans, J.
Popma, A.
Van der Laan, P. H.
Scherder, E. J. A.
Marhe, R.
Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title_full Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title_fullStr Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title_full_unstemmed Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title_short Neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
title_sort neurocognitive predictors of treatment completion and daytime activities at follow-up in multiproblem young adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497488/
https://www.ncbi.nlm.nih.gov/pubmed/32820418
http://dx.doi.org/10.3758/s13415-020-00822-4
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