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Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis

The purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is registered with PROSPERO (CRD42020170927). We searched PubMed, the Cochrane Library and EM...

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Autores principales: Zhao, J., Liang, G., Huang, H., Zeng, L., Yang, W., Pan, J., Liu, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497515/
https://www.ncbi.nlm.nih.gov/pubmed/32591972
http://dx.doi.org/10.1007/s00198-020-05508-8
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author Zhao, J.
Liang, G.
Huang, H.
Zeng, L.
Yang, W.
Pan, J.
Liu, J.
author_facet Zhao, J.
Liang, G.
Huang, H.
Zeng, L.
Yang, W.
Pan, J.
Liu, J.
author_sort Zhao, J.
collection PubMed
description The purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is registered with PROSPERO (CRD42020170927). We searched PubMed, the Cochrane Library and EMBASE for observational studies on the risk factors for falls in postmenopausal women. Review Manager 5.3 was used to calculate the relative risk (RR) or weighted mean difference (WMD) of potential risk factors related to falls. STATA 14.0 was used for the quantitative evaluation of publication bias. Eleven studies with 42,429 patients from 7 countries were included. The main risk factors for falls in postmenopausal women were patient sociodemographic risk factors (age: WMD = 0.37, 95% CI 0.07 to 0.68; body weight: WMD = 0.88, 95% CI 0.56 to 1.12; BMI: WMD = 0.34, 95% CI 0.21 to 0.46; exercise: RR = 0.97, 95% CI 0.94 to 0.99; and FES-I: WMD = 6.60, 95% CI 0.72 to 12.47) and medical risk factors (dietary calcium intake: WMD = − 16.91, 95% CI − 25.80 to − 8.01; previous fracture history: RR = 1.21, 95% CI 1.13 to 1.29; previous falls: RR = 2.02, 95% CI 1.91 to 2.14; number of diseases, ˃ 2: RR = 1.17, 95% CI 1.11 to 1.23; and number of reported chronic health disorders: WMD = 0.30, 95% CI 0.10 to 0.49). Knowledge of the many risk factors associated with falls in postmenopausal women can aid in fall prevention. However, we cannot rule out some additional potential risk factors (age at the onset of menopause, years since last menstruation, hormone therapy and BMD) that need further clinical research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00198-020-05508-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-74975152020-09-29 Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis Zhao, J. Liang, G. Huang, H. Zeng, L. Yang, W. Pan, J. Liu, J. Osteoporos Int Review The purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is registered with PROSPERO (CRD42020170927). We searched PubMed, the Cochrane Library and EMBASE for observational studies on the risk factors for falls in postmenopausal women. Review Manager 5.3 was used to calculate the relative risk (RR) or weighted mean difference (WMD) of potential risk factors related to falls. STATA 14.0 was used for the quantitative evaluation of publication bias. Eleven studies with 42,429 patients from 7 countries were included. The main risk factors for falls in postmenopausal women were patient sociodemographic risk factors (age: WMD = 0.37, 95% CI 0.07 to 0.68; body weight: WMD = 0.88, 95% CI 0.56 to 1.12; BMI: WMD = 0.34, 95% CI 0.21 to 0.46; exercise: RR = 0.97, 95% CI 0.94 to 0.99; and FES-I: WMD = 6.60, 95% CI 0.72 to 12.47) and medical risk factors (dietary calcium intake: WMD = − 16.91, 95% CI − 25.80 to − 8.01; previous fracture history: RR = 1.21, 95% CI 1.13 to 1.29; previous falls: RR = 2.02, 95% CI 1.91 to 2.14; number of diseases, ˃ 2: RR = 1.17, 95% CI 1.11 to 1.23; and number of reported chronic health disorders: WMD = 0.30, 95% CI 0.10 to 0.49). Knowledge of the many risk factors associated with falls in postmenopausal women can aid in fall prevention. However, we cannot rule out some additional potential risk factors (age at the onset of menopause, years since last menstruation, hormone therapy and BMD) that need further clinical research. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00198-020-05508-8) contains supplementary material, which is available to authorized users. Springer London 2020-06-26 2020 /pmc/articles/PMC7497515/ /pubmed/32591972 http://dx.doi.org/10.1007/s00198-020-05508-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Review
Zhao, J.
Liang, G.
Huang, H.
Zeng, L.
Yang, W.
Pan, J.
Liu, J.
Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title_full Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title_fullStr Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title_full_unstemmed Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title_short Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
title_sort identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497515/
https://www.ncbi.nlm.nih.gov/pubmed/32591972
http://dx.doi.org/10.1007/s00198-020-05508-8
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