Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP

[Image: see text] Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and pre...

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Autores principales: Lahdenpohja, Salla, Rajala, Noora A., Helin, Jatta S., Haaparanta-Solin, Merja, Solin, Olof, López-Picón, Francisco R., Kirjavainen, Anna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497626/
https://www.ncbi.nlm.nih.gov/pubmed/32479723
http://dx.doi.org/10.1021/acschemneuro.0c00313
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author Lahdenpohja, Salla
Rajala, Noora A.
Helin, Jatta S.
Haaparanta-Solin, Merja
Solin, Olof
López-Picón, Francisco R.
Kirjavainen, Anna K.
author_facet Lahdenpohja, Salla
Rajala, Noora A.
Helin, Jatta S.
Haaparanta-Solin, Merja
Solin, Olof
López-Picón, Francisco R.
Kirjavainen, Anna K.
author_sort Lahdenpohja, Salla
collection PubMed
description [Image: see text] Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical evaluation of a new CB1R specific radiotracer, [(18)F]FPATPP. [(18)F]FPATPP was produced with 16.7 ± 5.7% decay-corrected radiochemical yield and >95 GBq/μmol molar activity. The tracer showed high stability, low defluorination, and high specific binding to CB1Rs in mouse brain.
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spelling pubmed-74976262020-09-18 Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP Lahdenpohja, Salla Rajala, Noora A. Helin, Jatta S. Haaparanta-Solin, Merja Solin, Olof López-Picón, Francisco R. Kirjavainen, Anna K. ACS Chem Neurosci [Image: see text] Cannabinoid receptor 1 (CB1R) controls various physiological and pathological conditions, including memory, motivation, and inflammation, and is thus an interesting target for positron emission tomography (PET). Herein, we report a ruthenium-mediated radiolabeling synthesis and preclinical evaluation of a new CB1R specific radiotracer, [(18)F]FPATPP. [(18)F]FPATPP was produced with 16.7 ± 5.7% decay-corrected radiochemical yield and >95 GBq/μmol molar activity. The tracer showed high stability, low defluorination, and high specific binding to CB1Rs in mouse brain. American Chemical Society 2020-06-01 /pmc/articles/PMC7497626/ /pubmed/32479723 http://dx.doi.org/10.1021/acschemneuro.0c00313 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Lahdenpohja, Salla
Rajala, Noora A.
Helin, Jatta S.
Haaparanta-Solin, Merja
Solin, Olof
López-Picón, Francisco R.
Kirjavainen, Anna K.
Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title_full Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title_fullStr Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title_full_unstemmed Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title_short Ruthenium-Mediated (18)F-Fluorination and Preclinical Evaluation of a New CB(1) Receptor Imaging Agent [(18)F]FPATPP
title_sort ruthenium-mediated (18)f-fluorination and preclinical evaluation of a new cb(1) receptor imaging agent [(18)f]fpatpp
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497626/
https://www.ncbi.nlm.nih.gov/pubmed/32479723
http://dx.doi.org/10.1021/acschemneuro.0c00313
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