Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications

[Image: see text] Magnetic nanoparticles of Fe(3)O(4) doped by different amounts of Y(3+) (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements. An improved magnetization value was obtained for the Fe(3)O(4) sample with 1% Y(3+) doping. The specific absorption rate (SAR) and intrinsic loss of power (ILP) values for prepared colloids were obtained in water. The best results were estimated for Fe(3)O(4) with 0.1% Y(3+) ions (SAR = 194 W/g and ILP = 1.85 nHm(2)/kg for a magnetic field of 16 kA/m with the frequency of 413 kHz). The excellent biocompatibility with low cell cytotoxicity of Fe(3)O(4):Y nanoparticles was observed. Immediately after magnetic hyperthermia treatment with Fe(3)O(4):0.1%Y, a decrease in 4T1 cells’ viability was observed (77% for 35 μg/mL and 68% for 100 μg/mL). These results suggest that nanoparticles of Fe(3)O(4) doped by Y(3+) ions are suitable for biomedical applications, especially for hyperthermia treatment.