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How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?

In response to the current pandemic situation, we present the development of an effective virucidal and biocidal solution to prevent from the spread of infectious diseases through contact with contaminated surfaces. The disinfectants, based on equimolar mixtures of didecyldimethylammonium chloride (...

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Autores principales: Leclercq, Loïc, Nardello-Rataj, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497740/
https://www.ncbi.nlm.nih.gov/pubmed/32950617
http://dx.doi.org/10.1016/j.ejps.2020.105559
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author Leclercq, Loïc
Nardello-Rataj, Véronique
author_facet Leclercq, Loïc
Nardello-Rataj, Véronique
author_sort Leclercq, Loïc
collection PubMed
description In response to the current pandemic situation, we present the development of an effective virucidal and biocidal solution to prevent from the spread of infectious diseases through contact with contaminated surfaces. The disinfectants, based on equimolar mixtures of didecyldimethylammonium chloride ([DiC(10)][Cl]), dodecyloctaglycol (C(12)E(8)), and cyclodextrin (CD), show synergistic effects against enveloped viruses (RSV, HSV-1, VACV) and fungi (C. albicans), and additive responses against bacteria (P. aeruginosa). These synergistic mixtures could then be highly helpful for prevention of respiratory illnesses, since a boosted activity allows: (i) a faster eradication of pathogens, (ii) a shorter contact time, and (iii) a complete and broad-spectrum eradication to avoid spread of resistant strains (including bacteria and fungi).
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spelling pubmed-74977402020-09-18 How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus? Leclercq, Loïc Nardello-Rataj, Véronique Eur J Pharm Sci Article In response to the current pandemic situation, we present the development of an effective virucidal and biocidal solution to prevent from the spread of infectious diseases through contact with contaminated surfaces. The disinfectants, based on equimolar mixtures of didecyldimethylammonium chloride ([DiC(10)][Cl]), dodecyloctaglycol (C(12)E(8)), and cyclodextrin (CD), show synergistic effects against enveloped viruses (RSV, HSV-1, VACV) and fungi (C. albicans), and additive responses against bacteria (P. aeruginosa). These synergistic mixtures could then be highly helpful for prevention of respiratory illnesses, since a boosted activity allows: (i) a faster eradication of pathogens, (ii) a shorter contact time, and (iii) a complete and broad-spectrum eradication to avoid spread of resistant strains (including bacteria and fungi). Elsevier B.V. 2020-12-01 2020-09-17 /pmc/articles/PMC7497740/ /pubmed/32950617 http://dx.doi.org/10.1016/j.ejps.2020.105559 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Leclercq, Loïc
Nardello-Rataj, Véronique
How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title_full How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title_fullStr How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title_full_unstemmed How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title_short How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
title_sort how to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497740/
https://www.ncbi.nlm.nih.gov/pubmed/32950617
http://dx.doi.org/10.1016/j.ejps.2020.105559
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