MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension

BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II, a potent vasoconstrictor, to angiotensin-(1–7) and is also a membrane protein that enables coronavirus disease 2019 (COVID-19) infectivity. AMP-activated protein kinase (AMPK) phosphorylation of ACE2 enhances ACE2 stability....

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Detalles Bibliográficos
Autores principales: Shen, Hui, Zhang, Jiao, Wang, Chen, Jain, Pritesh P., Xiong, Mingmei, Shi, Xinxing, Lei, Yuyang, Chen, Shanshan, Yin, Qian, Thistlethwaite, Patricia A., Wang, Jian, Gong, Kaizheng, Yuan, Zu-Yi, Yuan, Jason X.-J., Shyy, John Y.-J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497891/
https://www.ncbi.nlm.nih.gov/pubmed/32755395
http://dx.doi.org/10.1161/CIRCULATIONAHA.120.048191

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