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On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer
PURPOSE: The number of dose‐limiting shells in the optimization process is one of the key factors determining the quality of stereotactic body radiotherapy (SBRT) auto‐planning in the Pinnacle treatment planning system (TPS). This study attempted to derive the optimal number of shells by evaluating...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497906/ https://www.ncbi.nlm.nih.gov/pubmed/32700823 http://dx.doi.org/10.1002/acm2.12983 |
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author | Duan, Yanhua Gan, Wutian Wang, Hao Chen, Hua Gu, Hengle Shao, Yan Feng, Aihui Ying, Yanchen Fu, Xiaolong Zhang, Chenchen Xu, Zhiyong Jeff Yue, Ning |
author_facet | Duan, Yanhua Gan, Wutian Wang, Hao Chen, Hua Gu, Hengle Shao, Yan Feng, Aihui Ying, Yanchen Fu, Xiaolong Zhang, Chenchen Xu, Zhiyong Jeff Yue, Ning |
author_sort | Duan, Yanhua |
collection | PubMed |
description | PURPOSE: The number of dose‐limiting shells in the optimization process is one of the key factors determining the quality of stereotactic body radiotherapy (SBRT) auto‐planning in the Pinnacle treatment planning system (TPS). This study attempted to derive the optimal number of shells by evaluating the auto‐plans designed with different number of shells for peripheral lung cancer patients treated with SBRT. METHODS: Identical treatment technique, optimization process, constraints, and dose calculation algorithm in the Pinnacle TPS were retrospectively applied to 50 peripheral lung cancer patients who underwent SBRT in our center. For each of the patients, auto‐plans were optimized based on two shells, three shells, four shells, five shells, six shells, seven shells, eight shells, respectively. The optimal number of shells for the SBRT auto‐planning was derived through the evaluations and comparisons of various dosimetric parameters of planning target volume (PTV) and organs at risk (OARs), monitor units (MU), and optimization time of the plans. RESULTS: The conformity index (CI) and the gradient index (GI) of PTV, the maximum dose outside the 2 cm of PTV (D(2cm)), D(max) of spinal cord (SC(max)), the percentage of volume of total lung excluding ITV receiving 20 Gy (V20) and 10 Gy (V10), and the mean lung dose (MLD) were improved when the number of shell increased, but the improvement became not significant as the number of shell reached six. The monitor units (MUs) varied little among different plans where no statistical differences were found. However, as the number of shell increased, the auto‐plan optimization time increased significantly. CONCLUSIONS: It appears that for peripheral lung SBRT plan using six shells can yield satisfactory plan quality with acceptable beam MUs and optimization time in the Pinnacle TPS. |
format | Online Article Text |
id | pubmed-7497906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74979062020-09-25 On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer Duan, Yanhua Gan, Wutian Wang, Hao Chen, Hua Gu, Hengle Shao, Yan Feng, Aihui Ying, Yanchen Fu, Xiaolong Zhang, Chenchen Xu, Zhiyong Jeff Yue, Ning J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: The number of dose‐limiting shells in the optimization process is one of the key factors determining the quality of stereotactic body radiotherapy (SBRT) auto‐planning in the Pinnacle treatment planning system (TPS). This study attempted to derive the optimal number of shells by evaluating the auto‐plans designed with different number of shells for peripheral lung cancer patients treated with SBRT. METHODS: Identical treatment technique, optimization process, constraints, and dose calculation algorithm in the Pinnacle TPS were retrospectively applied to 50 peripheral lung cancer patients who underwent SBRT in our center. For each of the patients, auto‐plans were optimized based on two shells, three shells, four shells, five shells, six shells, seven shells, eight shells, respectively. The optimal number of shells for the SBRT auto‐planning was derived through the evaluations and comparisons of various dosimetric parameters of planning target volume (PTV) and organs at risk (OARs), monitor units (MU), and optimization time of the plans. RESULTS: The conformity index (CI) and the gradient index (GI) of PTV, the maximum dose outside the 2 cm of PTV (D(2cm)), D(max) of spinal cord (SC(max)), the percentage of volume of total lung excluding ITV receiving 20 Gy (V20) and 10 Gy (V10), and the mean lung dose (MLD) were improved when the number of shell increased, but the improvement became not significant as the number of shell reached six. The monitor units (MUs) varied little among different plans where no statistical differences were found. However, as the number of shell increased, the auto‐plan optimization time increased significantly. CONCLUSIONS: It appears that for peripheral lung SBRT plan using six shells can yield satisfactory plan quality with acceptable beam MUs and optimization time in the Pinnacle TPS. John Wiley and Sons Inc. 2020-07-23 /pmc/articles/PMC7497906/ /pubmed/32700823 http://dx.doi.org/10.1002/acm2.12983 Text en © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Duan, Yanhua Gan, Wutian Wang, Hao Chen, Hua Gu, Hengle Shao, Yan Feng, Aihui Ying, Yanchen Fu, Xiaolong Zhang, Chenchen Xu, Zhiyong Jeff Yue, Ning On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title | On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title_full | On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title_fullStr | On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title_full_unstemmed | On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title_short | On the optimal number of dose‐limiting shells in the SBRT auto‐planning design for peripheral lung cancer |
title_sort | on the optimal number of dose‐limiting shells in the sbrt auto‐planning design for peripheral lung cancer |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497906/ https://www.ncbi.nlm.nih.gov/pubmed/32700823 http://dx.doi.org/10.1002/acm2.12983 |
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