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Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy

INTRODUCTION: Aim of this study is to dosimetrically characterize a new inorganic scintillator designed for magnetic resonance‐guided radiotherapy (MRgRT) in the presence of 0.35 tesla magnetic field (B). METHODS: The detector was characterized in terms of signal to noise ratio (SNR), reproducibilit...

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Autores principales: Cusumano, Davide, Placidi, Lorenzo, D'Agostino, Emiliano, Boldrini, Luca, Menna, Sebastiano, Valentini, Vincenzo, De Spirito, Marco, Azario, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497936/
https://www.ncbi.nlm.nih.gov/pubmed/32841500
http://dx.doi.org/10.1002/acm2.13012
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author Cusumano, Davide
Placidi, Lorenzo
D'Agostino, Emiliano
Boldrini, Luca
Menna, Sebastiano
Valentini, Vincenzo
De Spirito, Marco
Azario, Luigi
author_facet Cusumano, Davide
Placidi, Lorenzo
D'Agostino, Emiliano
Boldrini, Luca
Menna, Sebastiano
Valentini, Vincenzo
De Spirito, Marco
Azario, Luigi
author_sort Cusumano, Davide
collection PubMed
description INTRODUCTION: Aim of this study is to dosimetrically characterize a new inorganic scintillator designed for magnetic resonance‐guided radiotherapy (MRgRT) in the presence of 0.35 tesla magnetic field (B). METHODS: The detector was characterized in terms of signal to noise ratio (SNR), reproducibility, dose linearity, angular response, and dependence by energy, field size, and B orientation using a 6 MV magnetic resonance (MR)‐Linac and a water tank. Field size dependence was investigated by measuring the output factor (OF) at 1.5 cm. The results were compared with those measured using other detectors (ion chamber and synthetic diamond) and those calculated using a Monte Carlo (MC) algorithm. Energy dependence was investigated by acquiring a percentage depth dose (PDD) curve at two field sizes (3.32 × 3.32 and 9.96 × 9.96 cm(2)) and repeating the OF measurements at 5 and 10 cm depths. RESULTS: The mean SNR was 116.3 ± 0.6. Detector repeatability was within 1%, angular dependence was <2% and its response variation based on the orientation with respect to the B lines was <1%. The detector has a temporal resolution of 10 Hz and it showed a linear response (R(2) = 1) in the dose range investigated. All the OF values measured at 1.5 cm depth using the scintillator are in accordance within 1% with those measured with other detectors and are calculated using the MC algorithm. PDD values are in accordance with MC algorithm only for 3.32 × 3.32 cm(2) field. Numerical models can be applied to compensate for energy dependence in case of larger fields. CONCLUSION: The inorganic scintillator in the present form can represent a valuable detector for small‐field dosimetry and periodic quality controls at MR‐Linacs such as dose stability, OFs, and dose linearity. In particular, the detector can be effectively used for small‐field dosimetry at 1.5 cm depth and for PDD measurements if the field dimension of 3.32 × 3.32 cm(2) is not exceeded.
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spelling pubmed-74979362020-09-25 Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy Cusumano, Davide Placidi, Lorenzo D'Agostino, Emiliano Boldrini, Luca Menna, Sebastiano Valentini, Vincenzo De Spirito, Marco Azario, Luigi J Appl Clin Med Phys Radiation Measurements INTRODUCTION: Aim of this study is to dosimetrically characterize a new inorganic scintillator designed for magnetic resonance‐guided radiotherapy (MRgRT) in the presence of 0.35 tesla magnetic field (B). METHODS: The detector was characterized in terms of signal to noise ratio (SNR), reproducibility, dose linearity, angular response, and dependence by energy, field size, and B orientation using a 6 MV magnetic resonance (MR)‐Linac and a water tank. Field size dependence was investigated by measuring the output factor (OF) at 1.5 cm. The results were compared with those measured using other detectors (ion chamber and synthetic diamond) and those calculated using a Monte Carlo (MC) algorithm. Energy dependence was investigated by acquiring a percentage depth dose (PDD) curve at two field sizes (3.32 × 3.32 and 9.96 × 9.96 cm(2)) and repeating the OF measurements at 5 and 10 cm depths. RESULTS: The mean SNR was 116.3 ± 0.6. Detector repeatability was within 1%, angular dependence was <2% and its response variation based on the orientation with respect to the B lines was <1%. The detector has a temporal resolution of 10 Hz and it showed a linear response (R(2) = 1) in the dose range investigated. All the OF values measured at 1.5 cm depth using the scintillator are in accordance within 1% with those measured with other detectors and are calculated using the MC algorithm. PDD values are in accordance with MC algorithm only for 3.32 × 3.32 cm(2) field. Numerical models can be applied to compensate for energy dependence in case of larger fields. CONCLUSION: The inorganic scintillator in the present form can represent a valuable detector for small‐field dosimetry and periodic quality controls at MR‐Linacs such as dose stability, OFs, and dose linearity. In particular, the detector can be effectively used for small‐field dosimetry at 1.5 cm depth and for PDD measurements if the field dimension of 3.32 × 3.32 cm(2) is not exceeded. John Wiley and Sons Inc. 2020-08-25 /pmc/articles/PMC7497936/ /pubmed/32841500 http://dx.doi.org/10.1002/acm2.13012 Text en © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Measurements
Cusumano, Davide
Placidi, Lorenzo
D'Agostino, Emiliano
Boldrini, Luca
Menna, Sebastiano
Valentini, Vincenzo
De Spirito, Marco
Azario, Luigi
Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title_full Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title_fullStr Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title_full_unstemmed Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title_short Characterization of an inorganic scintillator for small‐field dosimetry in MR‐guided radiotherapy
title_sort characterization of an inorganic scintillator for small‐field dosimetry in mr‐guided radiotherapy
topic Radiation Measurements
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497936/
https://www.ncbi.nlm.nih.gov/pubmed/32841500
http://dx.doi.org/10.1002/acm2.13012
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