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Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram

PURPOSE: To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). METHODS: Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired...

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Autores principales: Huang, Jer-Shyung, Pan, Huay-Ben, Yang, Tsung-Lung, Hung, Bao-Hui, Chiang, Chia-Ling, Tsai, Meng-Yuan, Chou, Chen-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498093/
https://www.ncbi.nlm.nih.gov/pubmed/32941537
http://dx.doi.org/10.1371/journal.pone.0239271
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author Huang, Jer-Shyung
Pan, Huay-Ben
Yang, Tsung-Lung
Hung, Bao-Hui
Chiang, Chia-Ling
Tsai, Meng-Yuan
Chou, Chen-Pin
author_facet Huang, Jer-Shyung
Pan, Huay-Ben
Yang, Tsung-Lung
Hung, Bao-Hui
Chiang, Chia-Ling
Tsai, Meng-Yuan
Chou, Chen-Pin
author_sort Huang, Jer-Shyung
collection PubMed
description PURPOSE: To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). METHODS: Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2–4 min and 2–10 min, by comparing the signal intensity at the first time interval with that at the second. RESULTS: There were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2–4 min and 2–10 min frames according to two of the three readers’ interpretations (all p ≤ 0.001). CONCLUSION: Applications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM.
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spelling pubmed-74980932020-09-24 Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram Huang, Jer-Shyung Pan, Huay-Ben Yang, Tsung-Lung Hung, Bao-Hui Chiang, Chia-Ling Tsai, Meng-Yuan Chou, Chen-Pin PLoS One Research Article PURPOSE: To evaluate the kinetic patterns of benign and malignant breast lesions using contrast-enhanced digital mammogram (CEDM). METHODS: Women with suspicious breast lesions on mammography or ultrasound were enrolled. Single-view mediolateral oblique (MLO) CEDM of an affected breast was acquired at 2, 3, 4, 7, and 10 min after injection of contrast agent. Three readers visually and semi-quantitatively analyzed the enhancement of suspicious lesions. The kinetic pattern of each lesion was classified as persistent, plateau, or washout over two time intervals, 2–4 min and 2–10 min, by comparing the signal intensity at the first time interval with that at the second. RESULTS: There were 73 malignant and 75 benign lesions in 148 patients (mean age: 52 years). Benign and malignant breast lesions showed the highest signal intensity at 3 min and 2 min, respectively. Average areas under receiver operating characteristic (ROC) curve for diagnostic accuracy based on lesion enhancement at different time points were 0.73 at 2 min, 0.72 at 3 min, 0.69 at 4 min, 0.67 at 7 min, and 0.64 at 10 min. Diagnostic performance was significantly better at 2, 3, and 4 min than at 7 and 10 min (all p < 0.05). A washout kinetic pattern was significantly associated with malignant lesions at 2–4 min and 2–10 min frames according to two of the three readers’ interpretations (all p ≤ 0.001). CONCLUSION: Applications of optimal time intervals and kinetic patterns show promise in differentiation of benign and malignant breast lesions on CEDM. Public Library of Science 2020-09-17 /pmc/articles/PMC7498093/ /pubmed/32941537 http://dx.doi.org/10.1371/journal.pone.0239271 Text en © 2020 Huang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Huang, Jer-Shyung
Pan, Huay-Ben
Yang, Tsung-Lung
Hung, Bao-Hui
Chiang, Chia-Ling
Tsai, Meng-Yuan
Chou, Chen-Pin
Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title_full Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title_fullStr Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title_full_unstemmed Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title_short Kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
title_sort kinetic patterns of benign and malignant breast lesions on contrast enhanced digital mammogram
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498093/
https://www.ncbi.nlm.nih.gov/pubmed/32941537
http://dx.doi.org/10.1371/journal.pone.0239271
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