Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4(+) T cell decline and increased immune activation during acute infection

HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present...

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Detalles Bibliográficos
Autores principales: Macharia, Gladys N., Yue, Ling, Staller, Ecco, Dilernia, Dario, Wilkins, Daniel, Song, Heeyah, McGowan, Edward, King, Deborah, Fast, Pat, Imami, Nesrina, Price, Matthew A., Sanders, Eduard J., Hunter, Eric, Gilmour, Jill
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498102/
https://www.ncbi.nlm.nih.gov/pubmed/32886726
http://dx.doi.org/10.1371/journal.ppat.1008853

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