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Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials

Good Participatory Practice (GPP) guidelines support and direct community engagement practices in biomedical HIV prevention trials, however no standardized metrics define the implementation and evaluation of these practices. Collaboratively, the Community Program staff of the HIV Vaccine Trials Netw...

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Autores principales: Broder, Gail B., Lucas, Jonathan P., Davis, Jontraye, Wallace, Stephaun E., Luthuli, Nandisile, Baepanye, Kagisho, White, Rhonda R., Bolton, Marcus, Blanchette, Cheryl, Andrasik, Michele P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498108/
https://www.ncbi.nlm.nih.gov/pubmed/32941520
http://dx.doi.org/10.1371/journal.pone.0239276
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author Broder, Gail B.
Lucas, Jonathan P.
Davis, Jontraye
Wallace, Stephaun E.
Luthuli, Nandisile
Baepanye, Kagisho
White, Rhonda R.
Bolton, Marcus
Blanchette, Cheryl
Andrasik, Michele P.
author_facet Broder, Gail B.
Lucas, Jonathan P.
Davis, Jontraye
Wallace, Stephaun E.
Luthuli, Nandisile
Baepanye, Kagisho
White, Rhonda R.
Bolton, Marcus
Blanchette, Cheryl
Andrasik, Michele P.
author_sort Broder, Gail B.
collection PubMed
description Good Participatory Practice (GPP) guidelines support and direct community engagement practices in biomedical HIV prevention trials, however no standardized metrics define the implementation and evaluation of these practices. Collaboratively, the Community Program staff of the HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) created a metric to describe, monitor, and evaluate one component of GPP, recruitment practices, in two HIV monoclonal Antibody Mediated Prevention (AMP) clinical trials, HVTN 703/HPTN 081 and HVTN 704/HPTN 085. Through consultation with community representatives from each clinical research site (hereafter “site(s)”), who made up the study Community Working Groups, recruitment strategy descriptors were developed for both trials to characterize responses to “How did you hear about the AMP study?” The Community Working Groups also helped to define and establish time points that were selected to allow comparisons across sites. Data were collected by 43 of 46 clinical research sites from January 1, 2017 to February 28, 2018. All 43 sites used multiple recruitment strategies successfully, but strategies varied by region. Globally, referrals was the most efficient and effective recruitment strategy as evidenced by the screening: enrollment ratio of 2.2:1 in Africa, and 2.1:1 in the Americas/Switzerland. Print materials were also valuable globally (3:1 Africa, 4.2:1 Americas/Switzerland). In Africa, in-person outreach was also quite effective (2.3:1) and led to the most enrollments (748 of 1186, 63%). In the Americas/Switzerland, outreach was also effective (2.6:1), but internet use resulted in the most screens (1893 of 4275, 44%) and enrollments (677 of 1531, 44%), compared to 12 of 2887 (0.4%) and 2 of 1204 (0.1%) in Africa, respectively. Standardized metrics and data collection aid meaningful comparisons of optimal community engagement methods for trial enrollment. Internet strategies had better success in the Americas/Switzerland than in sub-Saharan African countries. Data are essential in outreach staff efforts to improve screening-to-enrollment ratios. Because the effectiveness of recruitment strategies varies by region, it is critical that clinical research sites tailor community engagement and recruitment strategies to their local environment, and that they are supported with resources enabling use of a range of approaches.
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spelling pubmed-74981082020-09-24 Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials Broder, Gail B. Lucas, Jonathan P. Davis, Jontraye Wallace, Stephaun E. Luthuli, Nandisile Baepanye, Kagisho White, Rhonda R. Bolton, Marcus Blanchette, Cheryl Andrasik, Michele P. PLoS One Research Article Good Participatory Practice (GPP) guidelines support and direct community engagement practices in biomedical HIV prevention trials, however no standardized metrics define the implementation and evaluation of these practices. Collaboratively, the Community Program staff of the HIV Vaccine Trials Network (HVTN) and the HIV Prevention Trials Network (HPTN) created a metric to describe, monitor, and evaluate one component of GPP, recruitment practices, in two HIV monoclonal Antibody Mediated Prevention (AMP) clinical trials, HVTN 703/HPTN 081 and HVTN 704/HPTN 085. Through consultation with community representatives from each clinical research site (hereafter “site(s)”), who made up the study Community Working Groups, recruitment strategy descriptors were developed for both trials to characterize responses to “How did you hear about the AMP study?” The Community Working Groups also helped to define and establish time points that were selected to allow comparisons across sites. Data were collected by 43 of 46 clinical research sites from January 1, 2017 to February 28, 2018. All 43 sites used multiple recruitment strategies successfully, but strategies varied by region. Globally, referrals was the most efficient and effective recruitment strategy as evidenced by the screening: enrollment ratio of 2.2:1 in Africa, and 2.1:1 in the Americas/Switzerland. Print materials were also valuable globally (3:1 Africa, 4.2:1 Americas/Switzerland). In Africa, in-person outreach was also quite effective (2.3:1) and led to the most enrollments (748 of 1186, 63%). In the Americas/Switzerland, outreach was also effective (2.6:1), but internet use resulted in the most screens (1893 of 4275, 44%) and enrollments (677 of 1531, 44%), compared to 12 of 2887 (0.4%) and 2 of 1204 (0.1%) in Africa, respectively. Standardized metrics and data collection aid meaningful comparisons of optimal community engagement methods for trial enrollment. Internet strategies had better success in the Americas/Switzerland than in sub-Saharan African countries. Data are essential in outreach staff efforts to improve screening-to-enrollment ratios. Because the effectiveness of recruitment strategies varies by region, it is critical that clinical research sites tailor community engagement and recruitment strategies to their local environment, and that they are supported with resources enabling use of a range of approaches. Public Library of Science 2020-09-17 /pmc/articles/PMC7498108/ /pubmed/32941520 http://dx.doi.org/10.1371/journal.pone.0239276 Text en © 2020 Broder et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Broder, Gail B.
Lucas, Jonathan P.
Davis, Jontraye
Wallace, Stephaun E.
Luthuli, Nandisile
Baepanye, Kagisho
White, Rhonda R.
Bolton, Marcus
Blanchette, Cheryl
Andrasik, Michele P.
Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title_full Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title_fullStr Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title_full_unstemmed Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title_short Standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in HIV prevention trials
title_sort standardized metrics can reveal region-specific opportunities in community engagement to aid recruitment in hiv prevention trials
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498108/
https://www.ncbi.nlm.nih.gov/pubmed/32941520
http://dx.doi.org/10.1371/journal.pone.0239276
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