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QT interval measurement with portable device during COVID-19 outbreak
Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been u...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498206/ https://www.ncbi.nlm.nih.gov/pubmed/32964098 http://dx.doi.org/10.1016/j.ijcha.2020.100644 |
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author | González, Nerea Torres Acosta, Luis Álvarez Miranda, Diego Valdivia Plasencia, Alejandro Iriarte Cáceres, Virginia Barreto Zambrano, Marx Rivera Afonso, Julio Salvador Hernández |
author_facet | González, Nerea Torres Acosta, Luis Álvarez Miranda, Diego Valdivia Plasencia, Alejandro Iriarte Cáceres, Virginia Barreto Zambrano, Marx Rivera Afonso, Julio Salvador Hernández |
author_sort | González, Nerea Torres |
collection | PubMed |
description | Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat this disease may prolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth connectivity. After a validation study with 50 patients, we found a very good correlation between the QT interval measured both with this device and with the conventional body surface ECG. In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes. All patients with drug induced QT prolongation corrected the QT interval following the indications of the protocol, and no patients died of arrhythmic causes after its implementation. In our experience, a protocol for the electrocardiographic monitoring of these patients minimizes the risk of iatrogenic QT interval prolongation and consequently reduces sudden death events, and for that purpose, portable devices like the one used in this protocol may constitute a useful tool to minimize the contact with such patients. |
format | Online Article Text |
id | pubmed-7498206 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74982062020-09-18 QT interval measurement with portable device during COVID-19 outbreak González, Nerea Torres Acosta, Luis Álvarez Miranda, Diego Valdivia Plasencia, Alejandro Iriarte Cáceres, Virginia Barreto Zambrano, Marx Rivera Afonso, Julio Salvador Hernández Int J Cardiol Heart Vasc Original Paper Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat this disease may prolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth connectivity. After a validation study with 50 patients, we found a very good correlation between the QT interval measured both with this device and with the conventional body surface ECG. In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes. All patients with drug induced QT prolongation corrected the QT interval following the indications of the protocol, and no patients died of arrhythmic causes after its implementation. In our experience, a protocol for the electrocardiographic monitoring of these patients minimizes the risk of iatrogenic QT interval prolongation and consequently reduces sudden death events, and for that purpose, portable devices like the one used in this protocol may constitute a useful tool to minimize the contact with such patients. Elsevier 2020-09-17 /pmc/articles/PMC7498206/ /pubmed/32964098 http://dx.doi.org/10.1016/j.ijcha.2020.100644 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper González, Nerea Torres Acosta, Luis Álvarez Miranda, Diego Valdivia Plasencia, Alejandro Iriarte Cáceres, Virginia Barreto Zambrano, Marx Rivera Afonso, Julio Salvador Hernández QT interval measurement with portable device during COVID-19 outbreak |
title | QT interval measurement with portable device during COVID-19 outbreak |
title_full | QT interval measurement with portable device during COVID-19 outbreak |
title_fullStr | QT interval measurement with portable device during COVID-19 outbreak |
title_full_unstemmed | QT interval measurement with portable device during COVID-19 outbreak |
title_short | QT interval measurement with portable device during COVID-19 outbreak |
title_sort | qt interval measurement with portable device during covid-19 outbreak |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498206/ https://www.ncbi.nlm.nih.gov/pubmed/32964098 http://dx.doi.org/10.1016/j.ijcha.2020.100644 |
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