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QT interval measurement with portable device during COVID-19 outbreak

Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been u...

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Autores principales: González, Nerea Torres, Acosta, Luis Álvarez, Miranda, Diego Valdivia, Plasencia, Alejandro Iriarte, Cáceres, Virginia Barreto, Zambrano, Marx Rivera, Afonso, Julio Salvador Hernández
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498206/
https://www.ncbi.nlm.nih.gov/pubmed/32964098
http://dx.doi.org/10.1016/j.ijcha.2020.100644
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author González, Nerea Torres
Acosta, Luis Álvarez
Miranda, Diego Valdivia
Plasencia, Alejandro Iriarte
Cáceres, Virginia Barreto
Zambrano, Marx Rivera
Afonso, Julio Salvador Hernández
author_facet González, Nerea Torres
Acosta, Luis Álvarez
Miranda, Diego Valdivia
Plasencia, Alejandro Iriarte
Cáceres, Virginia Barreto
Zambrano, Marx Rivera
Afonso, Julio Salvador Hernández
author_sort González, Nerea Torres
collection PubMed
description Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat this disease may prolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth connectivity. After a validation study with 50 patients, we found a very good correlation between the QT interval measured both with this device and with the conventional body surface ECG. In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes. All patients with drug induced QT prolongation corrected the QT interval following the indications of the protocol, and no patients died of arrhythmic causes after its implementation. In our experience, a protocol for the electrocardiographic monitoring of these patients minimizes the risk of iatrogenic QT interval prolongation and consequently reduces sudden death events, and for that purpose, portable devices like the one used in this protocol may constitute a useful tool to minimize the contact with such patients.
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spelling pubmed-74982062020-09-18 QT interval measurement with portable device during COVID-19 outbreak González, Nerea Torres Acosta, Luis Álvarez Miranda, Diego Valdivia Plasencia, Alejandro Iriarte Cáceres, Virginia Barreto Zambrano, Marx Rivera Afonso, Julio Salvador Hernández Int J Cardiol Heart Vasc Original Paper Coronavirus Disease 2019 continues to spread and to date, no definitive treatment is available. Overcrowded and under-resourced healthcare centres have had to design different strategies to treat these patients, what includes the control of the electrocardiogram (ECG), as some drugs that have been used to treat this disease may prolong the QT interval as a side effect. During the COVID-19 outbreak, we designed a protocol for monitoring the QT interval using a portable device with Bluetooth connectivity. After a validation study with 50 patients, we found a very good correlation between the QT interval measured both with this device and with the conventional body surface ECG. In this article, we provide a brief overview of the protocol and then analyse the QT changes observed in a group of patients during their hospitalization and treatment for SARS-CoV-2 infection. 81 patients with confirmed SARS-CoV-2 infection were enrolled in the protocol (age 63.4 SD 17.2 years; 70.3% men), while being treated with lopinavir/ritonavir, azithromycin and hydroxychloroquine, both individually or combined. Ten patients developed long drug-related QT interval, and the QT prolongation was statically significant for all treatment schemes. All patients with drug induced QT prolongation corrected the QT interval following the indications of the protocol, and no patients died of arrhythmic causes after its implementation. In our experience, a protocol for the electrocardiographic monitoring of these patients minimizes the risk of iatrogenic QT interval prolongation and consequently reduces sudden death events, and for that purpose, portable devices like the one used in this protocol may constitute a useful tool to minimize the contact with such patients. Elsevier 2020-09-17 /pmc/articles/PMC7498206/ /pubmed/32964098 http://dx.doi.org/10.1016/j.ijcha.2020.100644 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
González, Nerea Torres
Acosta, Luis Álvarez
Miranda, Diego Valdivia
Plasencia, Alejandro Iriarte
Cáceres, Virginia Barreto
Zambrano, Marx Rivera
Afonso, Julio Salvador Hernández
QT interval measurement with portable device during COVID-19 outbreak
title QT interval measurement with portable device during COVID-19 outbreak
title_full QT interval measurement with portable device during COVID-19 outbreak
title_fullStr QT interval measurement with portable device during COVID-19 outbreak
title_full_unstemmed QT interval measurement with portable device during COVID-19 outbreak
title_short QT interval measurement with portable device during COVID-19 outbreak
title_sort qt interval measurement with portable device during covid-19 outbreak
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498206/
https://www.ncbi.nlm.nih.gov/pubmed/32964098
http://dx.doi.org/10.1016/j.ijcha.2020.100644
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