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Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19

INTRODUCTION AND OBJECTIVES: Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The obj...

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Autores principales: Solano-López, Jorge, Zamorano, José Luis, Pardo Sanz, Ana, Amat-Santos, Ignacio, Sarnago, Fernando, Gutiérrez Ibañes, Enrique, Sanchis, Juan, Rey Blas, Juan Ramón, Gómez-Hospital, Joan Antoni, Santos Martínez, Sandra, Maneiro-Melón, Nicolás Manuel, Mateos Gaitán, Roberto, González D’Gregorio, Jessika, Salido, Luisa, Mestre, José L., Sanmartín, Marcelo, Sánchez-Recalde, Ángel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498230/
https://www.ncbi.nlm.nih.gov/pubmed/32963419
http://dx.doi.org/10.1016/j.recesp.2020.07.023
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author Solano-López, Jorge
Zamorano, José Luis
Pardo Sanz, Ana
Amat-Santos, Ignacio
Sarnago, Fernando
Gutiérrez Ibañes, Enrique
Sanchis, Juan
Rey Blas, Juan Ramón
Gómez-Hospital, Joan Antoni
Santos Martínez, Sandra
Maneiro-Melón, Nicolás Manuel
Mateos Gaitán, Roberto
González D’Gregorio, Jessika
Salido, Luisa
Mestre, José L.
Sanmartín, Marcelo
Sánchez-Recalde, Ángel
author_facet Solano-López, Jorge
Zamorano, José Luis
Pardo Sanz, Ana
Amat-Santos, Ignacio
Sarnago, Fernando
Gutiérrez Ibañes, Enrique
Sanchis, Juan
Rey Blas, Juan Ramón
Gómez-Hospital, Joan Antoni
Santos Martínez, Sandra
Maneiro-Melón, Nicolás Manuel
Mateos Gaitán, Roberto
González D’Gregorio, Jessika
Salido, Luisa
Mestre, José L.
Sanmartín, Marcelo
Sánchez-Recalde, Ángel
author_sort Solano-López, Jorge
collection PubMed
description INTRODUCTION AND OBJECTIVES: Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The objective of this study was to describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during the COVID-19 pandemic. METHODS: This prospective, multicenter, cohort study included all consecutive patients with AMI who underwent coronary angiography in a 30-day period corresponding chronologically with the COVID-19 outbreak (March 15 to April 15, 2020). Clinical presentations and outcomes were compared between COVID-19 and non-COVID-19 patients. The effect of COVID-19 on mortality was assessed by propensity score matching and with a multivariate logistic regression model. RESULTS: In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% [P < .001] and 15.2% vs 1.8% [P = .001], respectively). GRACE score > 140 (OR, 23.45; 95%CI, 2.52–62.51; P = .005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43; P = .02) were independent predictors of in-hospital death. CONCLUSIONS: During this pandemic, a high GRACE score and COVID-19 were independent risk factors associated with higher in-hospital mortality. Full English text available from:www.revespcardiol.org/en
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spelling pubmed-74982302020-09-18 Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19 Solano-López, Jorge Zamorano, José Luis Pardo Sanz, Ana Amat-Santos, Ignacio Sarnago, Fernando Gutiérrez Ibañes, Enrique Sanchis, Juan Rey Blas, Juan Ramón Gómez-Hospital, Joan Antoni Santos Martínez, Sandra Maneiro-Melón, Nicolás Manuel Mateos Gaitán, Roberto González D’Gregorio, Jessika Salido, Luisa Mestre, José L. Sanmartín, Marcelo Sánchez-Recalde, Ángel Rev Esp Cardiol Artículo Original INTRODUCTION AND OBJECTIVES: Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The objective of this study was to describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during the COVID-19 pandemic. METHODS: This prospective, multicenter, cohort study included all consecutive patients with AMI who underwent coronary angiography in a 30-day period corresponding chronologically with the COVID-19 outbreak (March 15 to April 15, 2020). Clinical presentations and outcomes were compared between COVID-19 and non-COVID-19 patients. The effect of COVID-19 on mortality was assessed by propensity score matching and with a multivariate logistic regression model. RESULTS: In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% [P < .001] and 15.2% vs 1.8% [P = .001], respectively). GRACE score > 140 (OR, 23.45; 95%CI, 2.52–62.51; P = .005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43; P = .02) were independent predictors of in-hospital death. CONCLUSIONS: During this pandemic, a high GRACE score and COVID-19 were independent risk factors associated with higher in-hospital mortality. Full English text available from:www.revespcardiol.org/en Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. 2020-12 2020-09-17 /pmc/articles/PMC7498230/ /pubmed/32963419 http://dx.doi.org/10.1016/j.recesp.2020.07.023 Text en © 2020 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Artículo Original
Solano-López, Jorge
Zamorano, José Luis
Pardo Sanz, Ana
Amat-Santos, Ignacio
Sarnago, Fernando
Gutiérrez Ibañes, Enrique
Sanchis, Juan
Rey Blas, Juan Ramón
Gómez-Hospital, Joan Antoni
Santos Martínez, Sandra
Maneiro-Melón, Nicolás Manuel
Mateos Gaitán, Roberto
González D’Gregorio, Jessika
Salido, Luisa
Mestre, José L.
Sanmartín, Marcelo
Sánchez-Recalde, Ángel
Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title_full Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title_fullStr Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title_full_unstemmed Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title_short Factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la COVID-19
title_sort factores de riesgo de muerte hospitalaria en pacientes con infarto agudo de miocardio durante la pandemia de la covid-19
topic Artículo Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498230/
https://www.ncbi.nlm.nih.gov/pubmed/32963419
http://dx.doi.org/10.1016/j.recesp.2020.07.023
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