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Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report

The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous impact on the world. Owing to limited data available, it remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease. We describe a moderate...

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Autores principales: Mathiasen, Victor Dahl, Oversoe, Stine Karlsen, Ott, Peter, Jensen-Fangel, Søren, Leth, Steffen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498236/
https://www.ncbi.nlm.nih.gov/pubmed/33039144
http://dx.doi.org/10.1016/j.transproceed.2020.09.007
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author Mathiasen, Victor Dahl
Oversoe, Stine Karlsen
Ott, Peter
Jensen-Fangel, Søren
Leth, Steffen
author_facet Mathiasen, Victor Dahl
Oversoe, Stine Karlsen
Ott, Peter
Jensen-Fangel, Søren
Leth, Steffen
author_sort Mathiasen, Victor Dahl
collection PubMed
description The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous impact on the world. Owing to limited data available, it remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease. We describe a moderate course of coronavirus disease 2019 (COVID-19) in a patient who underwent a liver transplant 2 years earlier because of Budd-Chiari syndrome. The patient presented with malaise, headache, dry cough, and fever for 4 days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. Oxygen therapy was given for a single night, and the patient gradually recovered with supportive care only. With this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with higher mortality.
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spelling pubmed-74982362020-09-18 Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report Mathiasen, Victor Dahl Oversoe, Stine Karlsen Ott, Peter Jensen-Fangel, Søren Leth, Steffen Transplant Proc COVID-19 Minisymposium: Towards a Strategic Roadmap The global outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had an enormous impact on the world. Owing to limited data available, it remains unclear to what extent liver transplant recipients should be considered at a higher risk of severe disease. We describe a moderate course of coronavirus disease 2019 (COVID-19) in a patient who underwent a liver transplant 2 years earlier because of Budd-Chiari syndrome. The patient presented with malaise, headache, dry cough, and fever for 4 days. Immunosuppressive therapy with tacrolimus and mycophenolate mofetil was continued throughout the course of infection. Oxygen therapy was given for a single night, and the patient gradually recovered with supportive care only. With this case report, we demonstrate that liver transplantation and immunosuppression is not necessarily associated with severe COVID-19 and emphasize that more information on this matter is urgently required. Withdrawal of immunosuppressive therapy could be associated with higher mortality. Elsevier Inc. 2020-11 2020-09-17 /pmc/articles/PMC7498236/ /pubmed/33039144 http://dx.doi.org/10.1016/j.transproceed.2020.09.007 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle COVID-19 Minisymposium: Towards a Strategic Roadmap
Mathiasen, Victor Dahl
Oversoe, Stine Karlsen
Ott, Peter
Jensen-Fangel, Søren
Leth, Steffen
Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title_full Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title_fullStr Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title_full_unstemmed Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title_short Recovery of Moderate Coronavirus Disease 2019 in a Liver Transplant Recipient on Continued Immunosuppression: A Case Report
title_sort recovery of moderate coronavirus disease 2019 in a liver transplant recipient on continued immunosuppression: a case report
topic COVID-19 Minisymposium: Towards a Strategic Roadmap
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498236/
https://www.ncbi.nlm.nih.gov/pubmed/33039144
http://dx.doi.org/10.1016/j.transproceed.2020.09.007
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