Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains

The type III CRISPR–Cas systems provide immunity against invading nucleic acids through the coordinated transcription-dependent DNA targeting and cyclic adenylate (cA(n))-activated RNA degradation. Here, we show that both these pathways contribute to the Streptococcus thermophilus (St) type III-A CR...

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Detalles Bibliográficos
Autores principales: Smalakyte, Dalia, Kazlauskiene, Migle, F. Havelund, Jesper, Rukšėnaitė, Audronė, Rimaite, Auguste, Tamulaitiene, Giedre, Færgeman, Nils J, Tamulaitis, Gintautas, Siksnys, Virginijus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498309/
https://www.ncbi.nlm.nih.gov/pubmed/32766806
http://dx.doi.org/10.1093/nar/gkaa634

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