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Targeted DNA oxidation by LSD1–SMAD2/3 primes TGF-β1/ EMT genes for activation or repression

The epithelial-to-mesenchymal transition (EMT) is a complex transcriptional program induced by transforming growth factor β1 (TGF-β1). Histone lysine-specific demethylase 1 (LSD1) has been recognized as a key mediator of EMT in cancer cells, but the precise mechanism that underlies the activation an...

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Detalles Bibliográficos
Autores principales:	Pezone, Antonio, Taddei, Maria Letizia, Tramontano, Alfonso, Dolcini, Jacopo, Boffo, Francesca Ludovica, De Rosa, Mariarosaria, Parri, Matteo, Stinziani, Stefano, Comito, Giuseppina, Porcellini, Antonio, Raugei, Giovanni, Gackowski, Daniel, Zarakowska, Ewelina, Olinski, Ryszard, Gabrielli, Armando, Chiarugi, Paola, Avvedimento, Enrico Vittorio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498341/ https://www.ncbi.nlm.nih.gov/pubmed/32697292 http://dx.doi.org/10.1093/nar/gkaa599

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