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Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring
Statistical analysis of single cell RNA-sequencing (scRNA-seq) data is hindered by high levels of technical noise and inflated zero counts. One promising approach for addressing these challenges is gene set testing, or pathway analysis, which can mitigate sparsity and noise, and improve interpretati...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498348/ https://www.ncbi.nlm.nih.gov/pubmed/32633778 http://dx.doi.org/10.1093/nar/gkaa582 |