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Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation
As its name implies, the DNA dependent protein kinase (DNA-PK) requires DNA double-stranded ends for enzymatic activation. Here, I demonstrate that hairpinned DNA ends are ineffective for activating the kinase toward many of its well-studied substrates (p53, XRCC4, XLF, HSP90). However, hairpinned D...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498359/ https://www.ncbi.nlm.nih.gov/pubmed/32716029 http://dx.doi.org/10.1093/nar/gkaa614 |