Structure of two G-quadruplexes in equilibrium in the KRAS promoter

KRAS is one of the most mutated oncogenes and still considered an undruggable target. An alternative strategy would consist in targeting its gene rather than the protein, specifically the formation of G-quadruplexes (G4) in its promoter. G4 are secondary structures implicated in biological processes...

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Detalles Bibliográficos
Autores principales: Marquevielle, Julien, Robert, Coralie, Lagrabette, Olivier, Wahid, Mona, Bourdoncle, Anne, Xodo, Luigi E, Mergny, Jean-Louis, Salgado, Gilmar F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498360/
https://www.ncbi.nlm.nih.gov/pubmed/32432667
http://dx.doi.org/10.1093/nar/gkaa387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498360/
https://www.ncbi.nlm.nih.gov/pubmed/32432667
http://dx.doi.org/10.1093/nar/gkaa387

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