BRAF(V600E) drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation

BRAF(V600E) confers poor prognosis and is associated with a distinct subtype of colorectal cancer (CRC). Little is known, however, about the genetic events driving the initiation and progression of BRAF(V600E) mutant CRCs. Recent genetic analyses of CRCs indicate that BRAF(V600E) often coexists with...

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Detalles Bibliográficos
Autores principales: Reischmann, Nadine, Andrieux, Geoffroy, Griffin, Ricarda, Reinheckel, Thomas, Boerries, Melanie, Brummer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498370/
https://www.ncbi.nlm.nih.gov/pubmed/32792685
http://dx.doi.org/10.1038/s41388-020-01414-9

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