Cargando…
DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR
Lung cancer is the leading cause of cancer-associated mortality worldwide. DNA damage-regulated autophagy modulator 1 (DRAM1) plays an important roles in autophagy and tumor progression. However, the mechanisms by which DRAM1 inhibits tumor growth are not fully understood. Here, we report that DRAM1...
Autores principales: | Geng, Ji, Zhang, Rong, Yuan, Xiao, Xu, Haidong, Zhu, Zhou, Wang, Xinxin, Wang, Yan, Xu, Guoqiang, Guo, Wenjie, Wu, Junchao, Qin, Zheng-Hong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498585/ https://www.ncbi.nlm.nih.gov/pubmed/32943616 http://dx.doi.org/10.1038/s41419-020-02979-9 |
Ejemplares similares
-
EGFR-AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR-524-5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal Degradation
por: Xue, Yang, et al.
Publicado: (2022) -
DRAM1 Regulates Autophagy Flux through Lysosomes
por: Zhang, Xing-Ding, et al.
Publicado: (2013) -
DRAM1 regulates autophagy and cell proliferation via inhibition of the phosphoinositide 3-kinase-Akt-mTOR-ribosomal protein S6 pathway
por: Lu, Ting, et al.
Publicado: (2019) -
DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages
por: Banducci-Karp, Adrianna, et al.
Publicado: (2023) -
DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX
por: Guan, J-J, et al.
Publicado: (2015)