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Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection
Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vess...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498588/ https://www.ncbi.nlm.nih.gov/pubmed/32943639 http://dx.doi.org/10.1038/s41467-020-18454-0 |
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author | Siggins, Matthew K. Lynskey, Nicola N. Lamb, Lucy E. Johnson, Louise A. Huse, Kristin K. Pearson, Max Banerji, Suneale Turner, Claire E. Woollard, Kevin Jackson, David G. Sriskandan, Shiranee |
author_facet | Siggins, Matthew K. Lynskey, Nicola N. Lamb, Lucy E. Johnson, Louise A. Huse, Kristin K. Pearson, Max Banerji, Suneale Turner, Claire E. Woollard, Kevin Jackson, David G. Sriskandan, Shiranee |
author_sort | Siggins, Matthew K. |
collection | PubMed |
description | Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity. |
format | Online Article Text |
id | pubmed-7498588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74985882020-10-01 Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection Siggins, Matthew K. Lynskey, Nicola N. Lamb, Lucy E. Johnson, Louise A. Huse, Kristin K. Pearson, Max Banerji, Suneale Turner, Claire E. Woollard, Kevin Jackson, David G. Sriskandan, Shiranee Nat Commun Article Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus far ascribed only to cancer cells. Here, we report that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, transiting through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream. Contrasting with previously reported mechanisms of intracellular pathogen carriage by phagocytes, we show S. pyogenes remain extracellular during transit, first in afferent and then efferent lymphatics that carry the bacteria through successive draining lymph nodes. We identify streptococcal virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic streptococci within infected lymph nodes resist and subvert clearance by phagocytes, enabling replication that can seed intense bloodstream infection. The findings establish the lymphatic system as both a survival niche and conduit to the bloodstream for S. pyogenes, explaining the phenomenon of occult bacteraemia. This work provides new perspectives in streptococcal pathogenesis with implications for immunity. Nature Publishing Group UK 2020-09-17 /pmc/articles/PMC7498588/ /pubmed/32943639 http://dx.doi.org/10.1038/s41467-020-18454-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Siggins, Matthew K. Lynskey, Nicola N. Lamb, Lucy E. Johnson, Louise A. Huse, Kristin K. Pearson, Max Banerji, Suneale Turner, Claire E. Woollard, Kevin Jackson, David G. Sriskandan, Shiranee Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title | Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title_full | Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title_fullStr | Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title_full_unstemmed | Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title_short | Extracellular bacterial lymphatic metastasis drives Streptococcus pyogenes systemic infection |
title_sort | extracellular bacterial lymphatic metastasis drives streptococcus pyogenes systemic infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498588/ https://www.ncbi.nlm.nih.gov/pubmed/32943639 http://dx.doi.org/10.1038/s41467-020-18454-0 |
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