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A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Bicyclic peptides have great therapeutic potential since they can bridge the gap between small molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-like binding specificity. Here we apply a recently developed in silico rational design strategy to produce a bic...

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Detalles Bibliográficos
Autores principales:	Ikenoue, Tatsuya, Aprile, Francesco A., Sormanni, Pietro, Ruggeri, Francesco S., Perni, Michele, Heller, Gabriella T., Haas, Christian P., Middel, Christoph, Limbocker, Ryan, Mannini, Benedetta, Michaels, Thomas C. T., Knowles, Tuomas P. J., Dobson, Christopher M., Vendruscolo, Michele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498612/ https://www.ncbi.nlm.nih.gov/pubmed/32943652 http://dx.doi.org/10.1038/s41598-020-69626-3

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