Cargando…

Degrading AR-Dependent Cancers: Expanding the Role of PROTACs

Detalles Bibliográficos
Autores principales:	Michmerhuizen, Anna R., Speers, Corey
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2020
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498655/ https://www.ncbi.nlm.nih.gov/pubmed/32928364 http://dx.doi.org/10.1016/j.neo.2020.07.005

Ejemplares similares

Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog–Thalidomide PROTACs
por: Kim, Ga Yeong, et al.
Publicado: (2021)

ARe we there yet? Understanding androgen receptor signaling in breast cancer
por: Michmerhuizen, Anna R., et al.
Publicado: (2020)

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope
por: Ma, Sinan, et al.
Publicado: (2022)

An instructive attempt on developing aptamer-constructed PROTAC for breast cancer treatment
por: Zhang, Yuzhu, et al.
Publicado: (2022)

DeepPROTACs is a deep learning-based targeted degradation predictor for PROTACs
por: Li, Fenglei, et al.
Publicado: (2022)

Degradation of proteins by PROTACs and other strategies
por: Wang, Yang, et al.
Publicado: (2020)

Targeting Protein Kinases Degradation by PROTACs
por: Yu, Fei, et al.
Publicado: (2021)

A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo
por: Zhao, Lijie, et al.
Publicado: (2020)

Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity
por: Lu, Bin, et al.
Publicado: (2021)

PROTAC vaccine: A new way to live attenuated vaccines
por: Li, Zhen, et al.
Publicado: (2022)

PROTAC targeted protein degraders: the past is prologue
por: Békés, Miklós, et al.
Publicado: (2022)

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
por: Zhang, Qisi, et al.
Publicado: (2022)

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader
por: Tovell, Hannah, et al.
Publicado: (2019)

Tubulin Resists Degradation by Cereblon-Recruiting PROTACs
por: Gasic, Ivana, et al.
Publicado: (2020)

RNA‐PROTACs: Degraders of RNA‐Binding Proteins
por: Ghidini, Alice, et al.
Publicado: (2020)

Mutant-selective degradation by BRAF-targeting PROTACs
por: Alabi, Shanique, et al.
Publicado: (2021)

PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
por: Qi, Si-Min, et al.
Publicado: (2021)

PROTAC’ing oncoproteins: targeted protein degradation for cancer therapy
por: Kelm, Jeremy M., et al.
Publicado: (2023)

Proteasomal Degradation of Zn-Dependent Hdacs: The E3-Ligases Implicated and the Designed Protacs That Enable Degradation
por: Márquez-Cantudo, Laura, et al.
Publicado: (2021)

PROTAC-DB: an online database of PROTACs
por: Weng, Gaoqi, et al.
Publicado: (2020)

Light-Controllable PROTACs for Temporospatial Control of Protein Degradation
por: Liu, Jing, et al.
Publicado: (2021)

BacPROTACs mediate targeted protein degradation in bacteria
por: Morreale, Francesca E., et al.
Publicado: (2022)

Recent Advances of Degradation Technologies Based on PROTAC Mechanism
por: Xiao, Mingchao, et al.
Publicado: (2022)

A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer
por: Liao, Hongwei, et al.
Publicado: (2020)

Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer
por: Jin, Jinmei, et al.
Publicado: (2022)

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
por: Li, Xin, et al.
Publicado: (2020)

Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders
por: Hornberger, Keith R., et al.
Publicado: (2023)

PROTACs in gastrointestinal cancers
por: Chen, Yu, et al.
Publicado: (2022)

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4
por: Maneiro, María, et al.
Publicado: (2020)

Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers
por: Liu, Li, et al.
Publicado: (2022)

Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs
por: Gabizon, Ronen, et al.
Publicado: (2020)

Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
por: Zhang, Xiaoyu, et al.
Publicado: (2019)

Structural basis of PROTAC cooperative recognition for selective protein degradation
por: Gadd, Morgan S., et al.
Publicado: (2017)

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs
por: Naito, Mikihiko, et al.
Publicado: (2019)

Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs
por: Alabi, Shanique B., et al.
Publicado: (2021)

Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy
por: Yuan, Minghua, et al.
Publicado: (2021)

Design, synthesis, and biological evaluation of potent FAK-degrading PROTACs
por: Qin, Qiaohua, et al.
Publicado: (2022)

Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
por: Negi, Arvind, et al.
Publicado: (2022)

PROTAC-DB 2.0: an updated database of PROTACs
por: Weng, Gaoqi, et al.
Publicado: (2022)

Seviteronel, a Novel CYP17 Lyase Inhibitor and Androgen Receptor Antagonist, Radiosensitizes AR-Positive Triple Negative Breast Cancer Cells
por: Michmerhuizen, Anna R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ulu03ohlcubge22jk2mvaviiuu