Commentary on “The tortuous path of lactate shuttle discovery: From cinders and boards to the lab and ICU”

• Lactate is formed in skeletal muscles during fully oxygenated conditions. • Lactate shuttling between cells (known as the lactate shuttle) provides several important purposes for lactate (i.e., source of energy, gluconeogenic precursor, and signaling molecule). • Importantly, infusion of exogenous...

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Detalles Bibliográficos
Autor principal: Powers, Scott K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498666/
https://www.ncbi.nlm.nih.gov/pubmed/32928448
http://dx.doi.org/10.1016/j.jshs.2020.02.007
Descripción
Sumario:• Lactate is formed in skeletal muscles during fully oxygenated conditions. • Lactate shuttling between cells (known as the lactate shuttle) provides several important purposes for lactate (i.e., source of energy, gluconeogenic precursor, and signaling molecule). • Importantly, infusion of exogenous L-lactate is being evaluated in the treatment of a variety of human illnesses (e.g., heart failure, traumatic brain injury, etc.).

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