The roles of microRNA in redox metabolism and exercise-mediated adaptation

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage...

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Detalles Bibliográficos
Autores principales: Torma, Ferenc, Gombos, Zoltan, Jokai, Matyas, Berkes, Istvan, Takeda, Masaki, Mimura, Tatsuya, Radak, Zsolt, Gyori, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498669/
https://www.ncbi.nlm.nih.gov/pubmed/32780693
http://dx.doi.org/10.1016/j.jshs.2020.03.004
Descripción
Sumario:MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

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