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Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer

Objectives: This study aims to investigate the diagnostic and prognostic values of EpCAM, TGM2, and HE4 in endometrial cancer (EC). Methods: In this study, 42 patients diagnosed with EC (EC group), 41 patients diagnosed with myoma (benign group), and 43 healthy women (healthy group), who applied to...

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Autores principales: Lan, Ting, Mu, Chunyan, Wang, Zhongcheng, Wang, Yue, Li, Ying, Mai, Yueqin, Li, Shibao, Xu, Hao, Gu, Bing, Luo, Lan, Ma, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498689/
https://www.ncbi.nlm.nih.gov/pubmed/33014844
http://dx.doi.org/10.3389/fonc.2020.01697
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author Lan, Ting
Mu, Chunyan
Wang, Zhongcheng
Wang, Yue
Li, Ying
Mai, Yueqin
Li, Shibao
Xu, Hao
Gu, Bing
Luo, Lan
Ma, Ping
author_facet Lan, Ting
Mu, Chunyan
Wang, Zhongcheng
Wang, Yue
Li, Ying
Mai, Yueqin
Li, Shibao
Xu, Hao
Gu, Bing
Luo, Lan
Ma, Ping
author_sort Lan, Ting
collection PubMed
description Objectives: This study aims to investigate the diagnostic and prognostic values of EpCAM, TGM2, and HE4 in endometrial cancer (EC). Methods: In this study, 42 patients diagnosed with EC (EC group), 41 patients diagnosed with myoma (benign group), and 43 healthy women (healthy group), who applied to Affiliated Hospital of Xuzhou Medical University between March 2018 - September 2019 were recruited. Serum EpCAM, TGM2, and IL-33 levels were measured by ELISA, while serum HE4 and CA-125 levels were measured by ECLIA. The serum markers listed above were also measured in 12 paired pre- and post-operative EC patients. The diagnostic and prognostic values of serum markers were analyzed. Results: The serum EpCAM, TGM2, HE4, CA-125, and IL-33 levels were significantly higher in the EC group. The sensitivity and specificity of combined detection of EpCAM and HE4 was 92.86 and 69.05%, which were significantly higher than using a single marker or other combinations. Among these markers, serum HE4 levels were significantly higher in patients with myometrial invasion, metastasis, and lymphovascular invasion (p = 0.006, p = 0.0004, p = 0.0004, respectively). And serum TGM2 levels were significantly decreased in post-operative than that of pre-operative EC patients (p < 0.001). Conclusions: The combination of EpCAM and HE4 showed the highest specificity and sensitivity in the diagnosis of EC. HE4 was successful in the detection of high-risk individuals preoperatively. Additionally, TGM2 might be a prognostic factor for EC.
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spelling pubmed-74986892020-10-02 Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer Lan, Ting Mu, Chunyan Wang, Zhongcheng Wang, Yue Li, Ying Mai, Yueqin Li, Shibao Xu, Hao Gu, Bing Luo, Lan Ma, Ping Front Oncol Oncology Objectives: This study aims to investigate the diagnostic and prognostic values of EpCAM, TGM2, and HE4 in endometrial cancer (EC). Methods: In this study, 42 patients diagnosed with EC (EC group), 41 patients diagnosed with myoma (benign group), and 43 healthy women (healthy group), who applied to Affiliated Hospital of Xuzhou Medical University between March 2018 - September 2019 were recruited. Serum EpCAM, TGM2, and IL-33 levels were measured by ELISA, while serum HE4 and CA-125 levels were measured by ECLIA. The serum markers listed above were also measured in 12 paired pre- and post-operative EC patients. The diagnostic and prognostic values of serum markers were analyzed. Results: The serum EpCAM, TGM2, HE4, CA-125, and IL-33 levels were significantly higher in the EC group. The sensitivity and specificity of combined detection of EpCAM and HE4 was 92.86 and 69.05%, which were significantly higher than using a single marker or other combinations. Among these markers, serum HE4 levels were significantly higher in patients with myometrial invasion, metastasis, and lymphovascular invasion (p = 0.006, p = 0.0004, p = 0.0004, respectively). And serum TGM2 levels were significantly decreased in post-operative than that of pre-operative EC patients (p < 0.001). Conclusions: The combination of EpCAM and HE4 showed the highest specificity and sensitivity in the diagnosis of EC. HE4 was successful in the detection of high-risk individuals preoperatively. Additionally, TGM2 might be a prognostic factor for EC. Frontiers Media S.A. 2020-09-04 /pmc/articles/PMC7498689/ /pubmed/33014844 http://dx.doi.org/10.3389/fonc.2020.01697 Text en Copyright © 2020 Lan, Mu, Wang, Wang, Li, Mai, Li, Xu, Gu, Luo and Ma. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Lan, Ting
Mu, Chunyan
Wang, Zhongcheng
Wang, Yue
Li, Ying
Mai, Yueqin
Li, Shibao
Xu, Hao
Gu, Bing
Luo, Lan
Ma, Ping
Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title_full Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title_fullStr Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title_full_unstemmed Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title_short Diagnostic and Prognostic Values of Serum EpCAM, TGM2, and HE4 Levels in Endometrial Cancer
title_sort diagnostic and prognostic values of serum epcam, tgm2, and he4 levels in endometrial cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498689/
https://www.ncbi.nlm.nih.gov/pubmed/33014844
http://dx.doi.org/10.3389/fonc.2020.01697
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