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Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia

Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various life-threatening complications. Treatments primarily rely on orally administered potassium binding agents, along with low curative effects and various side effects. Herein, direct serum potassium up...

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Autores principales: Wang, Zhoujun, Sun, Wei, Wei, Zhiwei, Bao, Jianxu, Song, Xin, Li, Yupei, Ji, Haifeng, Zhang, Jue, He, Chao, Su, Baihai, Zhao, Weifeng, Zhao, Changsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498761/
https://www.ncbi.nlm.nih.gov/pubmed/32995679
http://dx.doi.org/10.1016/j.bioactmat.2020.08.032
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author Wang, Zhoujun
Sun, Wei
Wei, Zhiwei
Bao, Jianxu
Song, Xin
Li, Yupei
Ji, Haifeng
Zhang, Jue
He, Chao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
author_facet Wang, Zhoujun
Sun, Wei
Wei, Zhiwei
Bao, Jianxu
Song, Xin
Li, Yupei
Ji, Haifeng
Zhang, Jue
He, Chao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
author_sort Wang, Zhoujun
collection PubMed
description Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various life-threatening complications. Treatments primarily rely on orally administered potassium binding agents, along with low curative effects and various side effects. Herein, direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads. The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution, the fabrication of microbeads via zeolite-mixing, electro-spraying and phase-inversion, and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching. An ultra-high (about 88%) amount of zeolite could be incorporated and well locked inside the polymer matrix. Potassium uptake capability was verified in water, normal saline and human serum, showing high selectivity and fast adsorption. The microbeads exhibited satisfying blood compatibility, negligible hemolysis ratio, prolonged clotting time, inhibited contact activation, and enhanced antifouling property toward serum proteins and cells. The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap, efficient and safe treatment protocol of hyperkalemia for the high-risk patients.
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spelling pubmed-74987612020-09-28 Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia Wang, Zhoujun Sun, Wei Wei, Zhiwei Bao, Jianxu Song, Xin Li, Yupei Ji, Haifeng Zhang, Jue He, Chao Su, Baihai Zhao, Weifeng Zhao, Changsheng Bioact Mater Article Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various life-threatening complications. Treatments primarily rely on orally administered potassium binding agents, along with low curative effects and various side effects. Herein, direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads. The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution, the fabrication of microbeads via zeolite-mixing, electro-spraying and phase-inversion, and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching. An ultra-high (about 88%) amount of zeolite could be incorporated and well locked inside the polymer matrix. Potassium uptake capability was verified in water, normal saline and human serum, showing high selectivity and fast adsorption. The microbeads exhibited satisfying blood compatibility, negligible hemolysis ratio, prolonged clotting time, inhibited contact activation, and enhanced antifouling property toward serum proteins and cells. The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap, efficient and safe treatment protocol of hyperkalemia for the high-risk patients. KeAi Publishing 2020-09-12 /pmc/articles/PMC7498761/ /pubmed/32995679 http://dx.doi.org/10.1016/j.bioactmat.2020.08.032 Text en © 2020 [The Author/The Authors] https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wang, Zhoujun
Sun, Wei
Wei, Zhiwei
Bao, Jianxu
Song, Xin
Li, Yupei
Ji, Haifeng
Zhang, Jue
He, Chao
Su, Baihai
Zhao, Weifeng
Zhao, Changsheng
Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title_full Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title_fullStr Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title_full_unstemmed Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title_short Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
title_sort selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498761/
https://www.ncbi.nlm.nih.gov/pubmed/32995679
http://dx.doi.org/10.1016/j.bioactmat.2020.08.032
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