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Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma
Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaques covering a limited area of the skin and normally follows an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498821/ https://www.ncbi.nlm.nih.gov/pubmed/33015047 http://dx.doi.org/10.3389/fcell.2020.00851 |
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author | Stolearenco, Veronica Namini, Martin R. J. Hasselager, Siri S. Gluud, Maria Buus, Terkild B. Willerslev-Olsen, Andreas Ødum, Niels Krejsgaard, Thorbjørn |
author_facet | Stolearenco, Veronica Namini, Martin R. J. Hasselager, Siri S. Gluud, Maria Buus, Terkild B. Willerslev-Olsen, Andreas Ødum, Niels Krejsgaard, Thorbjørn |
author_sort | Stolearenco, Veronica |
collection | PubMed |
description | Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaques covering a limited area of the skin and normally follows an indolent course. However, in a subset of patients the cutaneous lesions develop into tumors and the malignant T cells may spread to the lymphatic system, blood and internal organs with fatal consequences. Despite intensive research, the mechanisms driving disease progression remain incompletely understood. While most studies have focused on cancer cell-intrinsic oncogenesis, such as genetic and epigenetic events driving malignant transformation and disease progression, an increasing body of evidence shows that the interplay between malignant T cells and non-malignant cells plays a crucial role. Here, we outline some of the emerging mechanisms by which tumor, stromal and epidermal interactions may contribute to the progression of CTCL with particular emphasis on the crosstalk between fibroblasts, keratinocytes and malignant T cells. |
format | Online Article Text |
id | pubmed-7498821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74988212020-10-02 Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma Stolearenco, Veronica Namini, Martin R. J. Hasselager, Siri S. Gluud, Maria Buus, Terkild B. Willerslev-Olsen, Andreas Ødum, Niels Krejsgaard, Thorbjørn Front Cell Dev Biol Cell and Developmental Biology Cutaneous T-cell lymphoma (CTCL) comprises a group of lymphoproliferative diseases characterized by the accumulation of malignant T cells in chronically inflamed skin lesions. In early stages, the disease presents as skin patches or plaques covering a limited area of the skin and normally follows an indolent course. However, in a subset of patients the cutaneous lesions develop into tumors and the malignant T cells may spread to the lymphatic system, blood and internal organs with fatal consequences. Despite intensive research, the mechanisms driving disease progression remain incompletely understood. While most studies have focused on cancer cell-intrinsic oncogenesis, such as genetic and epigenetic events driving malignant transformation and disease progression, an increasing body of evidence shows that the interplay between malignant T cells and non-malignant cells plays a crucial role. Here, we outline some of the emerging mechanisms by which tumor, stromal and epidermal interactions may contribute to the progression of CTCL with particular emphasis on the crosstalk between fibroblasts, keratinocytes and malignant T cells. Frontiers Media S.A. 2020-09-04 /pmc/articles/PMC7498821/ /pubmed/33015047 http://dx.doi.org/10.3389/fcell.2020.00851 Text en Copyright © 2020 Stolearenco, Namini, Hasselager, Gluud, Buus, Willerslev-Olsen, Ødum and Krejsgaard. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Stolearenco, Veronica Namini, Martin R. J. Hasselager, Siri S. Gluud, Maria Buus, Terkild B. Willerslev-Olsen, Andreas Ødum, Niels Krejsgaard, Thorbjørn Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title | Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title_full | Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title_fullStr | Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title_full_unstemmed | Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title_short | Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma |
title_sort | cellular interactions and inflammation in the pathogenesis of cutaneous t-cell lymphoma |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498821/ https://www.ncbi.nlm.nih.gov/pubmed/33015047 http://dx.doi.org/10.3389/fcell.2020.00851 |
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